Udongwo Ndausung, Mararenko Anton, Alchalabi Halah, Amin Tasnuva, Lesniak Christopher, Sharif Khawaja Umar
Internal Medicine, Jersey Shore University Medical Center, Neptune, USA.
Endocrinology, Diabetes and Metabolism, Mount Sinai Medical Center, New York , USA.
Cureus. 2021 Aug 7;13(8):e16983. doi: 10.7759/cureus.16983. eCollection 2021 Aug.
Acute pancreatitis is a common reason for hospitalization in the United States and can have a high degree of morbidity and mortality if not treated appropriately. Establishing the diagnosis and following guideline-directed medical therapy are both important. In the Western world, the most common causes include acute alcohol overuse, hypertriglyceridemia, gallstone pancreatitis, post-instrumentation including endoscopic cholangiopancreatography, and medication side effects. Our team describes the case of an 84-year-old male that was found to have acute pancreatitis secondary to repaglinide, a commonly used medication for the management of diabetes mellitus. The diagnosis was made based on the imaging findings, physical examination, and the corresponding laboratory markers. The patient was also found to have a blood-alcohol level at baseline and triglyceride levels within normal range. The patient's symptoms resolved with the cessation of repaglinide administration. Our team hopes to make the medical community more aware of the potential association between repaglinide and the potentially rapidly debilitating disease.
在美国，急性胰腺炎是住院治疗的常见病因，如果治疗不当，可能会导致高度的发病率和死亡率。确立诊断并遵循指南指导的药物治疗都很重要。在西方世界，最常见的病因包括急性酒精过量使用、高甘油三酯血症、胆石性胰腺炎、包括内镜逆行胰胆管造影术在内的术后情况以及药物副作用。我们的团队描述了一名84岁男性的病例，该患者被发现患有因瑞格列奈（一种常用于治疗糖尿病的药物）继发的急性胰腺炎。诊断是基于影像学检查结果、体格检查以及相应的实验室指标做出的。患者在基线时血液酒精水平正常，甘油三酯水平也在正常范围内。停用瑞格列奈后，患者的症状得到缓解。我们的团队希望让医学界更加了解瑞格列奈与这种可能迅速使人衰弱的疾病之间的潜在关联。
