恶性胸膜间皮瘤：全面综述
Malignant pleural mesothelioma: a comprehensive review.
作者信息
Ismail-Khan Roohi, Robinson Lary A, Williams Charles C, Garrett Christopher R, Bepler Gerold, Simon George R
机构信息
Thoracic Oncology Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
出版信息
Cancer Control. 2006 Oct;13(4):255-63. doi: 10.1177/107327480601300402.
BACKGROUND
The incidence of malignant mesothelioma continues to increase, but the disease remains difficult to detect early and treat effectively.
METHODS
The authors review the pathogenesis, incidence, clinical presentation, diagnosis, pathology, and both standard and experimental treatments for mesothelioma.
RESULTS
When possible, surgery (video-assisted thoracoscopy, pleurectomy/decortication, or extrapleural pneumonectomy) is utilized. Effects on underlying structures limit application of radiation therapy, but some systemic agents are beginning to enhance survival.
CONCLUSIONS
The disease is expected to increase in incidence till 2020, so awareness of this entity as a possible diagnosis should be heightened. In patients with advanced disease, several newer antitumor agents are already showing a capability of extending survival so it is not unreasonable to expect further progress in this area.
背景
恶性间皮瘤的发病率持续上升，但该疾病仍难以早期检测和有效治疗。
方法
作者回顾了间皮瘤的发病机制、发病率、临床表现、诊断、病理学以及标准和实验性治疗方法。
结果
在可能的情况下，采用手术（电视辅助胸腔镜手术、胸膜切除术/去皮质术或胸膜外全肺切除术）。对深层结构的影响限制了放射治疗的应用，但一些全身性药物已开始提高生存率。
结论
预计到2020年该疾病的发病率将上升，因此应提高对这一可能诊断的认识。在晚期疾病患者中，几种新型抗肿瘤药物已显示出延长生存期的能力，因此预计该领域会有进一步进展并非不合理。
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