Luster Joshua D, Galindo Ricardo
Medicine, Brooke Army Medical Center, San Antonio, USA.
Cureus. 2021 Aug 18;13(8):e17273. doi: 10.7759/cureus.17273. eCollection 2021 Aug.
Posterior reversible encephalopathy syndrome (PRES) is a symptomatic and radiographic syndrome characterized by neurologic changes and concomitant neuroimaging findings typically involving posterior cerebral white matter edema. While there are many competing views on the pathophysiology of PRES, inflammatory conditions, particularly autoimmune diseases, tend to have some degree of correlation. Most cases where patients who have PRES and autoimmune diseases typically involve systemic lupus erythematosus. There is relatively little information in the literature on PRES occurring in adult patients with hemophagocytic lymphohistiocytosis (HLH)/macrophage activation syndrome or of concomitant herpes simplex virus 2 (HSV2) infection. Here, we present the case of a patient with PRES in the setting of adult-onset Still's disease and HLH with concomitant HSV2 infection.
后部可逆性脑病综合征（PRES）是一种有症状和影像学表现的综合征，其特征为神经系统改变以及相应的神经影像学表现，通常累及大脑后部白质水肿。虽然关于PRES的病理生理学存在许多不同观点，但炎症性疾病，尤其是自身免疫性疾病，往往与之存在一定程度的关联。大多数患有PRES和自身免疫性疾病的患者病例通常涉及系统性红斑狼疮。关于噬血细胞性淋巴组织细胞增生症（HLH）/巨噬细胞活化综合征成年患者发生PRES或合并单纯疱疹病毒2型（HSV2）感染的文献资料相对较少。在此，我们报告一例成年斯蒂尔病和HLH患者合并HSV2感染时发生PRES的病例。
