Sun Chang, Wang Yu-Tong, Dai Yu-Jie, Liu Zhi-Hui, Yang Jing, Cheng Zhu-Qiang, Dong Dao-Song, Wang Cheng-Fu, Zhao Guo-Li, Lu Gui-Jun, Song Tao, Jin Yi, Kaye Alan D, Imani Farnad, Sadegi Kambiz, Sun Li-Li, Sun Yong-Hai
Department of Orthopedics, Xijing Hospital, The Fourth Military Medical University (Air Force Medical University), Xi'an, China.
Department of Anesthesiology, Anesthesia and Operation Center, Chinese PLA General Hospital, Beijing, China.
Anesth Pain Med. 2021 Jun 29;11(3):e115873. doi: 10.5812/aapm.115873. eCollection 2021 Jun.
The cisterna Intrathecal Drug Delivery system (IDDS) with morphine has proven to be effective in treating refractory cancer pain above the middle thoracic vertebrae level in some countries. However, it has not been fully investigated in others. We designed the current project to investigate the efficacy and safety of cisterna IDDS for pain relief in refractory pain above the middle thoracic vertebrae level in advanced cancer patients.
This study protocol allows for eligible cancer patients to receive the cisterna IDDS operation. Pain intensity (Visual Analogue scale, VAS), quality of life (36-Item Short-Form Health Survey, SF-36), and depression (Self-Rating Depression scale, SDS) are assessed along with side effects in the postoperative follow-up visits. Recent literature suggests a potential role for cisterna IDDS morphine delivery for refractory pain states above the middle thoracic level.
The results of this study may provide further evidence that cisterna IDDS of morphine can serve as an effective and safe pain relief strategy for refractory pain above the middle thoracic vertebrae level in advanced cancer patients.
在一些国家，鞘内药物输注系统（IDDS）联合吗啡已被证明对治疗胸中段以上水平的难治性癌痛有效。然而，在其他国家尚未对此进行充分研究。我们设计了本项目，以研究鞘内IDDS对晚期癌症患者胸中段以上水平难治性疼痛缓解的疗效和安全性。
本研究方案允许符合条件的癌症患者接受鞘内IDDS手术。在术后随访中评估疼痛强度（视觉模拟量表，VAS）、生活质量（36项简短健康调查，SF-36）和抑郁（自评抑郁量表，SDS）以及副作用。最近的文献表明，鞘内IDDS吗啡给药对胸中段以上水平的难治性疼痛状态具有潜在作用。
本研究结果可能提供进一步证据，表明鞘内IDDS吗啡可作为晚期癌症患者胸中段以上水平难治性疼痛的有效且安全的疼痛缓解策略。
