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长链非编码RNA AC007639.1通过抑制细胞凋亡和促进化疗耐药性促进肝细胞癌的发生发展。

Long Noncoding RNA AC007639.1 Promotes the Pathogenesis and Progression of Hepatocellular Carcinoma Through Inhibiting Apoptosis and Stimulating Chemotherapeutic Resistance.

作者信息

Bai Yun, Ding Meijuan, Lu Dan, Li Yiwen, Yao Shuai, Wang Lei, Li Hui, Cui Guanghua, Li Xue, Sun Xiaoke, Yang Yu

机构信息

Department of Oncology, Second Affiliated Hospital of Harbin Medical University, Harbin, China.

Department of Oncology, Harbin Medical University Cancer Hospital, Harbin, China.

出版信息

Front Oncol. 2021 Sep 2;11:715541. doi: 10.3389/fonc.2021.715541. eCollection 2021.

DOI:10.3389/fonc.2021.715541
PMID:34540685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8443795/
Abstract

BACKGROUND

Hepatocellular carcinoma (HCC) is known for its poor prognosis. Long noncoding RNAs (lncRNAs) are critical in the pathogenesis of various types of cancers. We tried to explore the role of lncRNA in the development of HCC.

METHODS

We identified the role of lncRNA AC007639.1 in the pathogenesis of HCC through bioinformatics and biological experiments in HepG2, Hep3B, and SMMC-7721 cells as well as the nude mice xenograft model.

RESULTS

We found that lncRNA AC007639.1 was overexpressed in hepatocellular carcinoma. Knocking down of lncRNA AC007639.1 by specific siRNAs or shRNAs promoted cancer cell death. The growth of mouse xenograft tumor created using lncRNA AC007639.1 deficient HepG2 cells was significantly slowed down. Furthermore, the knockdown of lncRNA AC007639.1 in HCC cells led to the increased expression of p53 and decreased expression of angiopoietin-like 4.

CONCLUSION

LncRNA AC007639.1 was involved in the pathogenesis and progression of hepatocellular carcinoma by inhibition of apoptosis and increasing HCC resistance to chemotherapy.

摘要

背景

肝细胞癌（HCC）预后较差。长链非编码RNA（lncRNAs）在各类癌症的发病机制中起关键作用。我们试图探究lncRNA在HCC发生发展中的作用。

方法

我们通过生物信息学以及在HepG2、Hep3B和SMMC-7721细胞中的生物学实验，还有裸鼠异种移植模型，确定了lncRNA AC007639.1在HCC发病机制中的作用。

结果

我们发现lncRNA AC007639.1在肝细胞癌中过表达。用特异性小干扰RNA（siRNAs）或短发夹RNA（shRNAs）敲低lncRNA AC007639.1可促进癌细胞死亡。使用缺乏lncRNA AC007639.1的HepG2细胞构建的小鼠异种移植瘤的生长显著减缓。此外，在HCC细胞中敲低lncRNA AC007639.1导致p53表达增加，血管生成素样4表达降低。

结论

lncRNA AC007639.1通过抑制细胞凋亡和增加HCC对化疗的抗性参与肝细胞癌的发病机制和进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94db/8443795/5ecd3825306d/fonc-11-715541-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94db/8443795/ffda1cee4eda/fonc-11-715541-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94db/8443795/5c4b0191f733/fonc-11-715541-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94db/8443795/89a224126770/fonc-11-715541-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94db/8443795/a9ef3984ad6b/fonc-11-715541-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94db/8443795/1141a4579e1b/fonc-11-715541-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94db/8443795/a88540a310e0/fonc-11-715541-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94db/8443795/5ecd3825306d/fonc-11-715541-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94db/8443795/ffda1cee4eda/fonc-11-715541-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94db/8443795/5c4b0191f733/fonc-11-715541-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94db/8443795/89a224126770/fonc-11-715541-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94db/8443795/a9ef3984ad6b/fonc-11-715541-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94db/8443795/1141a4579e1b/fonc-11-715541-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94db/8443795/a88540a310e0/fonc-11-715541-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/94db/8443795/5ecd3825306d/fonc-11-715541-g007.jpg

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