糖尿病患者的多种免疫功能损害及其对COVID-19的影响。
Multiple immune function impairments in diabetic patients and their effects on COVID-19.
作者信息
Lu Zhong-Hua, Yu Wei-Li, Sun Yun
机构信息
Department of Critical Care Medicine, The Second Affiliated Hospital, Anhui Medical University, Hefei 230601, Anhui Province, China.
出版信息
World J Clin Cases. 2021 Aug 26;9(24):6969-6978. doi: 10.12998/wjcc.v9.i24.6969.
Abstract
Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2, poses a significant threat to public health worldwide, and diabetes is considered a risk factor for the rapid progression and poor prognosis of COVID-19. Limited immune function is a clinical feature of COVID-19 patients, and diabetes patients have defects in innate and adaptive immune functions, which may be an important reason for the rapid progression and poor prognosis of COVID-19 in patients with diabetes. We review the possible multiple effects of immune impairment in diabetic patients on the immune responses to COVID-19 to provide guidance for the diagnosis and treatment of diabetic patients with COVID-19.
摘要
2019冠状病毒病（COVID-19）由严重急性呼吸综合征冠状病毒2引起，对全球公众健康构成重大威胁，糖尿病被认为是COVID-19快速进展和预后不良的一个危险因素。免疫功能受限是COVID-19患者的临床特征之一，而糖尿病患者存在先天性和适应性免疫功能缺陷，这可能是糖尿病患者COVID-19快速进展和预后不良的重要原因。我们综述了糖尿病患者免疫损伤对COVID-19免疫反应可能产生的多种影响，为COVID-19糖尿病患者的诊断和治疗提供指导。
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