Rajab Azza A H, Hegazy Wael A H
Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagzig 44511, Egypt.
World J Diabetes. 2023 Jun 15;14(6):680-704. doi: 10.4239/wjd.v14.i6.680.
Diabetes is a chronic disease that is considered one of the most stubborn global health problems that continues to defy the efforts of scientists and physicians. The prevalence of diabetes in the global population continues to grow to alarming levels year after year, causing an increase in the incidence of diabetes complications and health care costs all over the world. One major complication of diabetes is the high susceptibility to infections especially in the lower limbs due to the immunocompromised state of diabetic patients, which is considered a definitive factor in all cases. Diabetic foot infections continue to be one of the most common infections in diabetic patients that are associated with a high risk of serious complications such as bone infection, limb amputations, and life-threatening systemic infections. In this review, we discussed the circumstances associated with the high risk of infection in diabetic patients as well as some of the most commonly isolated pathogens from diabetic foot infections and the related virulence behavior. In addition, we shed light on the different treatment strategies that aim at eradicating the infection.
糖尿病是一种慢性病，被认为是最顽固的全球性健康问题之一，持续挑战着科学家和医生的努力。全球人口中糖尿病的患病率年复一年地持续增长至惊人水平，导致全球糖尿病并发症的发病率和医疗保健成本不断增加。糖尿病的一个主要并发症是患者易受感染，尤其是下肢，因为糖尿病患者处于免疫功能低下状态，这在所有病例中都被视为一个决定性因素。糖尿病足感染仍然是糖尿病患者中最常见的感染之一，与严重并发症如骨感染、肢体截肢和危及生命的全身感染的高风险相关。在本综述中，我们讨论了糖尿病患者感染高风险相关的情况，以及一些糖尿病足感染中最常分离出的病原体及其相关毒力行为。此外，我们还阐述了旨在根除感染的不同治疗策略。
