使用基础率方法定义的阿尔茨海默病与帕金森病所致轻度认知障碍患者的认知特征：对神经心理学评估的启示
Cognitive profiles of patients with mild cognitive impairment due to Alzheimer's versus Parkinson's disease defined using a base rate approach: Implications for neuropsychological assessments.
作者信息
Ophey Anja, Wolfsgruber Steffen, Roeske Sandra, Polcher Alexandra, Spottke Annika, Frölich Lutz, Hüll Michael, Jessen Frank, Kornhuber Johannes, Maier Wolfgang, Peters Oliver, Ramirez Alfredo, Wiltfang Jens, Liepelt-Scarfone Inga, Becker Sara, Berg Daniela, Schulz Jörg B, Reetz Kathrin, Wojtala Jennifer, Kassubek Jan, Storch Alexander, Balzer-Geldsetzer Monika, Hilker-Roggendorf Rüdiger, Witt Karsten, Mollenhauer Brit, Trenkwalder Claudia, Wittchen Hans-Ullrich, Riedel Oliver, Dodel Richard, Wagner Michael, Kalbe Elke
机构信息
Department of Medical Psychology Neuropsychology & Gender Studies; Center for Neuropsychological Diagnostics and Intervention (CeNDI) Faculty of Medicine and University Hospital Cologne, University of Cologne Cologne Germany.
Department of Neurodegenerative Diseases and Gerontopsychiatry University Hospital of Bonn University of Bonn Bonn Germany.
出版信息
Alzheimers Dement (Amst). 2021 Sep 14;13(1):e12223. doi: 10.1002/dad2.12223. eCollection 2021.
INTRODUCTION
Large studies on cognitive profiles of patients with mild cognitive impairment (MCI) due to Alzheimer's disease (AD-MCI) compared to Parkinson's disease (PD-MCI) are rare.
METHODS
Data from two multicenter cohort studies in AD and PD were merged using a unified base rate approach for the MCI diagnosis. Cognitive profiles were compared using scores derived from the Consortium to Establish a Registry for Alzheimer's Disease battery.
RESULTS
Patients with AD-MCI showed lower standardized scores on all memory test scores and a language test. Patients with PD-MCI showed lower standardized scores in a set-shifting measure as an executive task. A cross-validated logistic regression with test scores as predictors was able to classify 72% of patients correctly to AD-MCI versus PD-MCI.
DISCUSSION
The applied test battery successfully discriminated between AD-MCI and PD-MCI. Neuropsychological test batteries in clinical practice should always include a broad spectrum of cognitive domains to capture any cognitive changes.
引言
与帕金森病（PD-MCI）相比，针对阿尔茨海默病所致轻度认知障碍（AD-MCI）患者认知特征的大型研究较为罕见。
方法
采用统一的基础率方法进行MCI诊断，合并来自两项AD和PD多中心队列研究的数据。使用源自阿尔茨海默病注册协会成套测试得出的分数比较认知特征。
结果
AD-MCI患者在所有记忆测试分数和一项语言测试中标准化分数较低。PD-MCI患者在作为执行任务的定势转换测试中标准化分数较低。以测试分数为预测指标的交叉验证逻辑回归能够将72%的患者正确分类为AD-MCI与PD-MCI。
讨论
所应用的成套测试成功区分了AD-MCI和PD-MCI。临床实践中的神经心理成套测试应始终涵盖广泛的认知领域，以捕捉任何认知变化。
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