Zhang Mei, Zhang Xiaolin, Tian Taoran, Zhang Qi, Wen Yuting, Zhu Junyao, Xiao Dexuan, Cui Weitong, Lin Yunfeng
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, PR China.
College of Biomedical Engineering, Sichuan University, Chengdu, 610041, PR China.
Bioact Mater. 2021 Jun 11;8:368-380. doi: 10.1016/j.bioactmat.2021.06.003. eCollection 2022 Feb.
Gouty arthritis is a very familiar inflammatory arthritis. Controlling inflammation is the key to preventing gouty arthritis. However, colchicine, the most highly represented drug used in clinical practice, has strict contraindications owing to some severe side effects. Curcumin (Cur), a natural anti-inflammatory drug, has demonstrated good safety and efficacy. However, the rapid degradation, poor aqueous solubility, and low bioavailability of Cur limit its therapeutic effect. To strengthen the effectiveness and bioavailability of Cur. Cur loaded tetrahedral framework nucleic acids (Cur-TFNAs) were synthesized to deliver Cur. Compared with free Cur, Cur-TFNAs exhibit a preferable drug stability, good biocompatibility (CCK-8 assay), ease of uptake (immunofluorescence), and higher tissue utilization (in vivo biodistribution). Most importantly, Cur-TFNAs present better anti-inflammatory effect than free Cur both in vivo and in vitro experiments through the determination of inflammation-related cytokines expression. Therefore, we believe that Cur-TFNAs have great prospects for the prevention of gout and similar inflammatory diseases.
痛风性关节炎是一种非常常见的炎性关节炎。控制炎症是预防痛风性关节炎的关键。然而，秋水仙碱作为临床实践中使用最广泛的药物，由于一些严重的副作用而有严格的禁忌症。姜黄素（Cur）是一种天然抗炎药物，已显示出良好的安全性和疗效。然而，姜黄素的快速降解、较差的水溶性和低生物利用度限制了其治疗效果。为了增强姜黄素的有效性和生物利用度，合成了负载姜黄素的四面体框架核酸（Cur-TFNAs）来递送姜黄素。与游离姜黄素相比，Cur-TFNAs表现出更好的药物稳定性、良好的生物相容性（CCK-8测定）、易于摄取（免疫荧光）和更高的组织利用率（体内生物分布）。最重要的是，通过测定炎症相关细胞因子的表达，Cur-TFNAs在体内和体外实验中均表现出比游离姜黄素更好的抗炎作用。因此，我们认为Cur-TFNAs在预防痛风和类似炎性疾病方面具有广阔的前景。
