Mancebo-Azor Rafael, Sáez-Moreno José Antonio, Rodríguez-Ferrer José Manuel
Laboratory of Visual and Cognitive Neuroscience, Institute of Neuroscience, University of Granada, 18016 Granada, Spain.
Department of Clinical Neurophysiology, San Cecilio University Hospital, 18016 Granada, Spain.
Eur J Investig Health Psychol Educ. 2020 Oct 16;10(4):1010-1019. doi: 10.3390/ejihpe10040071.
To study the effect of check width size of the stimuli on the amplitude and latency of the P100 component of visual evoked potentials recorded in patients with retinitis pigmentosa (RP).
Pattern reversal visual evoked potentials (PVEPs) were recorded in 16 RP patients and 20 visually normal subjects. Pattern reversal stimuli with five different check widths and 100% of contrast were projected in the right eye of both patients and control subjects. PVEPs induced by stimuli with 78%, 16%, and 6% of contrast were also recorded in 10 of the control subjects.
In RP patients, the amplitude of P100 was smaller than controls in all check sized used and the peak P100 amplitude was obtained with a larger check width than in controls. P100 was also delayed in RP patients in all check sizes studied. The P100 amplitude- and latency-check size functions of RP patients were like those found in control subjects with low contrast stimuli of 16% and 6%.
The PVEPs spatial functions of RP patients show quantitative and qualitative changes, suggesting disease induced alteration in the neural processing of stimulus contrast.
研究刺激图形方格大小对视网膜色素变性（RP）患者视觉诱发电位P100成分的波幅和潜伏期的影响。
对16例RP患者和20名视力正常者记录图形翻转视觉诱发电位（PVEP）。在患者和对照者的右眼投射具有五种不同方格大小且对比度为100%的图形翻转刺激。还对10名对照者记录了对比度为78%、16%和6%的刺激所诱发的PVEP。
在RP患者中，所有使用的方格大小下P100的波幅均小于对照者，且获得峰值P100波幅时的方格大小比对照者更大。在所有研究的方格大小下，RP患者的P100也延迟。RP患者的P100波幅和潜伏期-方格大小函数与对比度为16%和6%的低对比度刺激的对照者中发现的函数相似。
RP患者的PVEP空间函数显示出定量和定性变化，提示疾病导致刺激对比度神经处理过程发生改变。
