Department of Anesthesiology and Perioperative Medicine, Pain Management, UCLA, 1245 16th Street #225, Santa Monica, CA, 90404, USA.
Department of Anesthesiology and Perioperative Medicine, UCLA, Los Angeles, CA, USA.
Cancer Treat Res. 2021;182:107-124. doi: 10.1007/978-3-030-81526-4_8.
Although opioids are potent central acting broad-spectrum analgesics, their effectiveness is diminished by various factors pertaining to their metabolism, drug interactions, genetic issues, adverse/side effects, and potential for abuse. All these factors present potential barriers to effective analgesia requiring specific considerations in clinical practice, which include monitoring and case-based intervention.
尽管阿片类药物是有效的中枢作用广谱镇痛药，但由于其代谢、药物相互作用、遗传问题、不良反应和滥用潜力等各种因素，其有效性会降低。所有这些因素都对有效的镇痛构成了潜在的障碍，这在临床实践中需要特别考虑，包括监测和基于病例的干预。
