Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
PLoS One. 2021 Sep 20;16(9):e0257630. doi: 10.1371/journal.pone.0257630. eCollection 2021.
Thrombocytopenia and leucopenia are frequently encountered hematological disorders among people living with HIV/AIDS. This systematic review and meta-analysis were aimed to indicate the national prevalence of thrombocytopenia and leucopenia among HIV/AIDS patients.
This systematic review and meta-analysis was conducted following the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. A systematic search was conducted from February 01, 2021 to April 02, 2021 using electronic databases Google Scholar, PubMed, Web of Sciences, Google, EMBASE, SCOPUS and ResearchGate. The quality of the included studies was assessed using Newcastle-Ottawa Quality Assessment Scale (NOS) adapted for cross-sectional studies. Data analysis was done using STATA version 14 using metan commands. Random effect meta-analysis was used to estimate the pooled prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS in Ethiopia.
Of the 349 initially searched articles, 90 were assessed for eligibility and only 13 articles published from 2014 to 2020 were included in the final meta-analysis. A total of 3854 participants were involved in the included studies. The pooled prevalence of thrombocytopenia was 9.69% (95%CI; 7.40-11.97%). Significant heterogeneity was observed with I2 value of 84.7%. Thrombocytopenia was 11.91% and 5.95% prevalent among HAART naive and HAART exposed HIV/AIDS patients, respectively. The pooled prevalence of leucopenia among HIV/AIDS patients was 17.31% (95%CI: 12.37-22.25%).
This study showed a high prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS, indicating the necessity of regular screening of HIV seropositive patients for different hematological parameters and providing treatment.
血小板减少和白细胞减少是艾滋病毒/艾滋病患者中常见的血液学障碍。本系统评价和荟萃分析旨在指出艾滋病毒/艾滋病患者血小板减少和白细胞减少的全国患病率。
本系统评价和荟萃分析按照系统评价和荟萃分析的首选报告项目（PRISMA）指南进行。从 2021 年 2 月 1 日至 2021 年 4 月 2 日，使用电子数据库 Google Scholar、PubMed、Web of Sciences、Google、EMBASE、SCOPUS 和 ResearchGate 进行了系统搜索。使用适用于横断面研究的纽卡斯尔-渥太华质量评估量表（NOS）评估纳入研究的质量。使用 STATA 版本 14 使用 metan 命令进行数据分析。使用随机效应荟萃分析估计埃塞俄比亚艾滋病毒感染者血小板减少和白细胞减少的总患病率。
在最初搜索的 349 篇文章中，有 90 篇文章进行了合格性评估，只有 13 篇发表于 2014 年至 2020 年的文章被纳入最终荟萃分析。共有 3854 名参与者参与了纳入的研究。血小板减少症的总患病率为 9.69%（95%CI；7.40-11.97%）。观察到 84.7%的 I2 值存在显著异质性。HAART 初治和暴露的 HIV/AIDS 患者的血小板减少症患病率分别为 11.91%和 5.95%。HIV/AIDS 患者白细胞减少症的总患病率为 17.31%（95%CI：12.37-22.25%）。
本研究表明，艾滋病毒感染者中血小板减少症和白细胞减少症的患病率较高，表明有必要定期对 HIV 血清阳性患者进行不同血液学参数的筛查，并提供治疗。
