Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Faculty of Medicine, Mahasarakham University, Mahasarakham 44000, Thailand.
Life Sci. 2021 Nov 15;285:119965. doi: 10.1016/j.lfs.2021.119965. Epub 2021 Sep 17.
Galangin is a natural flavonoid isolated from ginger, honey and propolis.
To investigate the effect of galangin on blood pressure, vascular changes, sympathoexcitation, oxidative stress and inflammation in rats treated with N-nitro-l-arginine methyl ester (l-NAME).
Male Wistar rats (220-250 g) were given l-NAME (0.5 mg/mL in drinking water) to induce hypertension for 5 weeks. They were treated with vehicle, galangin (30 or 60 mg/kg), or amlodipine (10 mg/kg) for the final two weeks (n = 6/group).
Galangin significantly reduced blood pressure and improved the impairment of endothelium-dependent vasodilation in hypertensive rats. Sympathoexcitation, including enhancement of contractile responses to electrical field stimulation, increases in intensity of tyrosine hydroxylase and plasma norepinephrine concentration in hypertensive rats, was attenuated by galangin treatment. Galangin also reduced systemic and vascular oxidative damage and increased plasma nitric oxide levels in the hypertensive groups. Aortic remodelling accompanied by aortic wall hypertrophy and fibrosis observed in hypertensive rats were alleviated by galangin treatment. Furthermore, galangin exhibited an anti-inflammatory effect by suppressing the upregulation of tumour necrosis factor receptor 1 (TNF-R1), phospho-nuclear factor kappa B (p-NF-κB) and vascular cell adhesion protein 1 (VCAM-1) in aortic tissue and reducing plasma tumour necrosis factor alpha (TNF-α) in l-NAME rats. In conclusion, galangin had antihypertensive effects that were relevant to attenuating endothelial dysfunction, sympathoexcitation and vascular remodelling. These effects might be contributed by antioxidant and anti-inflammatory capacities and modulation of the TNF-R1, p-NF-κB and VCAM-1 pathways in hypertensive rats.
姜黄、蜂蜜和蜂胶中分离出的天然类黄酮。
研究白杨素对 N-硝基-L-精氨酸甲酯（L-NAME）处理的大鼠血压、血管变化、交感神经兴奋、氧化应激和炎症的影响。
雄性 Wistar 大鼠（220-250g）给予 L-NAME（0.5mg/ml 饮用水）诱导高血压 5 周。在最后两周，它们用载体、白杨素（30 或 60mg/kg）或氨氯地平（10mg/kg）治疗（每组 n=6）。
白杨素可显著降低血压，改善高血压大鼠内皮依赖性血管舒张功能障碍。交感神经兴奋，包括增强对电场刺激的收缩反应、高血压大鼠酪氨酸羟化酶和血浆去甲肾上腺素浓度的增加，被白杨素治疗所减弱。白杨素还减轻了高血压大鼠的系统性和血管氧化损伤，并增加了血浆一氧化氮水平。在高血压大鼠中观察到的主动脉重塑伴有主动脉壁肥大和纤维化，经白杨素治疗后得到缓解。此外，白杨素通过抑制肿瘤坏死因子受体 1（TNF-R1）、磷酸核因子 kappa B（p-NF-κB）和血管细胞粘附蛋白 1（VCAM-1）在主动脉组织中的上调以及降低 L-NAME 大鼠血浆肿瘤坏死因子-α（TNF-α）来发挥抗炎作用。总之，白杨素有降压作用，与减轻内皮功能障碍、交感神经兴奋和血管重塑有关。这些作用可能是通过抗氧化和抗炎能力以及对 TNF-R1、p-NF-κB 和 VCAM-1 途径的调节来实现的。
