Bananzadeh Alimohammad, Mokhtari Maral, Sohooli Maryam, Shekouhi Ramin
Colorectal Research Center, Department of Surgery, Shiraz University of Medical Sciences, Shiraz, Iran.
Pathology Department, Shiraz University of Medical Sciences, Shiraz, Iran.
Int J Surg Case Rep. 2021 Oct;87:106420. doi: 10.1016/j.ijscr.2021.106420. Epub 2021 Sep 16.
Leiomyosarcoma (LMS) of the colon is an extremely rare and highly invasive tumor arising from the muscularis propria of the gastrointestinal tract. After the introduction of oncogenic role of KIT by immunohistochemistry (IHC), the reported cases of gastrointestinal leiomyosarcoma were highly limited. True LMS of the colon is such a rare disorder that there isn't much description of its nature.
We reported two very rare cases of primary leiomyosarcoma of sigmoid colon, which referred to our institution with symptoms of abdominal pain, lower GI bleeding and fatigue. After the initial investigations, both patients were diagnosed with primary LMS of sigmoid colon that underwent laparoscopic tumor resection.
The classical colonic LMS presents with a vast majority of non-specific symptoms including mild abdominal pain, fresh/obscure rectal bleeding, and weight loss. The most common location for colonic LMS is the sigmoid colon, and ascending colon. The prognostic factors for the disease outcome have not been established properly; however, patient age, tumor size/grade, and local/distant dissemination are of great importance.
Herein, we reported two rare cases of primary leiomyosarcoma of sigmoid colon that was treated with laparoscopic surgery.
结肠平滑肌肉瘤（LMS）是一种极其罕见且具有高度侵袭性的肿瘤，起源于胃肠道固有肌层。自通过免疫组织化学（IHC）发现KIT的致癌作用后，报道的胃肠道平滑肌肉瘤病例极为有限。结肠真性LMS是一种罕见疾病，对其性质的描述不多。
我们报告了两例非常罕见的乙状结肠原发性平滑肌肉瘤病例，这两位患者因腹痛、下消化道出血和疲劳症状转诊至我院。经过初步检查，两名患者均被诊断为乙状结肠原发性LMS，并接受了腹腔镜肿瘤切除术。
典型的结肠LMS表现为绝大多数非特异性症状，包括轻度腹痛、新鲜/隐匿性直肠出血和体重减轻。结肠LMS最常见的部位是乙状结肠和升结肠。该疾病预后因素尚未完全明确；然而，患者年龄、肿瘤大小/分级以及局部/远处转移非常重要。
在此，我们报告了两例采用腹腔镜手术治疗的乙状结肠原发性平滑肌肉瘤罕见病例。
