Al Laham Omar, Albrijawy Reham, Atia Fareed, Shaheen Jack, AlTabbakh Hani
Department of Surgery, Al-Mouwasat University Hospital, Mazzah, Damascus, Syria.
J Surg Case Rep. 2021 Nov 30;2021(11):rjab515. doi: 10.1093/jscr/rjab515. eCollection 2021 Nov.
Leiomyosarcoma (LMS) is a common form of soft tissue sarcoma. Primary colonic LMS is an extremely rare entity, comprising 1-2% of gastrointestinal malignancies. Primary mesenchymal sarcomas of the gastrointestinal system are rare and constitute just 0.1-3% of all gastrointestinal tumours. LMS is the most common variant of such tumours and represents just 0.12% of colorectal malignancies. We present a case of a 65-year-old female, who presented to the emergency department with 3 days history of obstipation and generalized abdominal pain. Radiology (X-ray and ultrasound) indicated a large pelvic mass compressing the sigmoid colon and its surrounding structures. Histopathological analysis indicated a primary LMS of the sigmoid colon. Diagnosis is established mostly postoperatively after histopathological evaluation. Prognosis and treatment modalities for this aggressive malignancy remain insufficient. LMS is relatively impervious to chemotherapy/radiotherapy. Our patient was treated by surgical excision of the tumour and referred postoperatively for adjuvant chemotherapy.
平滑肌肉瘤（LMS）是软组织肉瘤的一种常见形式。原发性结肠LMS是一种极其罕见的疾病，占胃肠道恶性肿瘤的1%-2%。胃肠道系统的原发性间充质肉瘤很罕见，仅占所有胃肠道肿瘤的0.1%-3%。LMS是此类肿瘤最常见的变体，仅占结直肠癌的0.12%。我们报告一例65岁女性病例，该患者因便秘3天和全腹疼痛就诊于急诊科。影像学检查（X线和超声）显示盆腔有一巨大肿块，压迫乙状结肠及其周围结构。组织病理学分析显示为乙状结肠原发性LMS。诊断主要在术后通过组织病理学评估确立。对于这种侵袭性恶性肿瘤的预后和治疗方式仍然不足。LMS对化疗/放疗相对不敏感。我们的患者接受了肿瘤手术切除，并在术后接受辅助化疗。
