Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Ghent University, Ghent, Belgium.
mBio. 2021 Oct 26;12(5):e0176321. doi: 10.1128/mBio.01763-21. Epub 2021 Sep 21.
A recent workshop titled "Developing Models to Study Polymicrobial Infections," sponsored by the Dartmouth Cystic Fibrosis Center (DartCF), explored the development of new models to study the polymicrobial infections associated with the airways of persons with cystic fibrosis (CF). The workshop gathered 35+ investigators over two virtual sessions. Here, we present the findings of this workshop, summarize some of the challenges involved with developing such models, and suggest three frameworks to tackle this complex problem. The frameworks proposed here, we believe, could be generally useful in developing new model systems for other infectious diseases. Developing and validating new approaches to study the complex polymicrobial communities in the CF airway could open windows to new therapeutics to treat these recalcitrant infections, as well as uncovering organizing principles applicable to chronic polymicrobial infections more generally.
最近由达特茅斯囊性纤维化中心（DartCF）主办的一个题为“开发用于研究多微生物感染的模型”的研讨会，探讨了开发新模型以研究与囊性纤维化（CF）患者气道相关的多微生物感染的方法。该研讨会在两个虚拟会议上聚集了 35 多名研究人员。在这里，我们介绍了这次研讨会的结果，总结了开发此类模型所涉及的一些挑战，并提出了三种解决这一复杂问题的框架。我们相信，这里提出的框架可以普遍用于为其他传染病开发新的模型系统。开发和验证研究 CF 气道中复杂多微生物群落的新方法，可以为治疗这些难治性感染开辟新的治疗途径，并揭示更普遍适用于慢性多微生物感染的组织原则。
