College of Science, Gansu Agricultural University, Lanzhou 730000, China.
College of Life Science, Gansu Agricultural University, Lanzhou 730000, China.
J Biomed Nanotechnol. 2021 Aug 1;17(8):1635-1646. doi: 10.1166/jbn.2021.3136.
Due to the combination of the high resolution of fluorescence imaging and the no limitation in penetration depth of magnetic resonance imaging, dual-mode imaging of magnetic resonance and fluorescence (MR/FI) have attracted extensive research in recent years. Herein, a novel MR/FI bimodal imaging probe is facile fabricated by attaching the rhodamine fluorophore covalently to the surface of the Gd-phenolic coordination polymer nanoparticles. The contents of Gd and RB of the as prepared probe are calculated to be 8.2% and 12.5%. The quantum yield of the probe is about 8.84% as well as red fluorescent emissive. The longitudinal r1 value is 6.94 mM s and the ratio r2/r1 is very low and about 1.22. Subsequently, the and MR imaging and fluorescence both and are performed. The metabolic pathways are inferred by studying the bio-distribution of the probe in major organs. The as-prepared probe exhibits excellent imaging performance and biocompatibility, which is conducive to its further application.
由于荧光成像的高分辨率和磁共振成像的穿透深度不受限制的结合，磁共振和荧光双模成像（MR/FI）近年来引起了广泛的研究。在此，通过将罗丹明荧光团共价连接到 Gd-苯氧配位聚合物纳米粒子的表面，简便地制备了一种新型的 MR/FI 双模成像探针。所制备探针中 Gd 和 RB 的含量计算为 8.2%和 12.5%。探针的量子产率约为 8.84%，并且具有红色荧光发射。纵向 r1 值为 6.94 mM s-1，并且 r2/r1 的比值非常低，约为 1.22。随后，进行了磁共振成像和荧光成像。通过研究探针在主要器官中的生物分布，推断出代谢途径。所制备的探针表现出优异的成像性能和生物相容性，有利于其进一步应用。
