Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Department of Neurology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA.
Parkinsonism Relat Disord. 2021 Sep;90:125-133. doi: 10.1016/j.parkreldis.2021.09.005. Epub 2021 Sep 14.
Gastrointestinal (GI) disorders have been thoroughly investigated in hypokinetic disorders such as Parkinson's disease, but much less is known about GI disorders in hyperkinetic movement disorders and ataxia. The aim of this review is to draw attention to the GI disorders that are associated with these movement disorders.
References for this systematic review were identified by searches of PubMed through May 2020. Only publications in English were reviewed.
Data from 249 articles were critically reviewed, compared, and integrated. The most frequently reported GI symptoms overall in hyperkinetic movement disorders and ataxia are dysphagia, sialorrhea, weight changes, esophago-gastritis, gastroparesis, constipation, diarrhea, and malabsorption. We report in detail on the frequency, characteristics, pathophysiology, and management of GI symptoms in essential tremor, restless legs syndrome, chorea, and spinocerebellar ataxias. The limited available data on GI disorders in dystonias, paroxysmal movement disorders, tardive dyskinesias, myoclonus, and non-SCA ataxias are also summarized.
The purpose of our systematic review is to draw attention that, although primarily motor disorders, hyperkinetic movement disorders and ataxia can involve the GI system. Raising awareness about the GI symptom burden in hyperkinetic movement disorders and ataxia could contribute to a new research interest in that field, as well as improved patient care.
胃肠道（GI）疾病在运动减少性疾病（如帕金森病）中已得到深入研究，但在运动过多性运动障碍和共济失调中，GI 疾病知之甚少。本综述的目的是引起人们对与这些运动障碍相关的胃肠道疾病的关注。
通过 2020 年 5 月对 PubMed 的检索，确定了本系统综述的参考文献。仅综述了英文出版物。
对 249 篇文章的数据进行了批判性回顾、比较和整合。在运动过多性运动障碍和共济失调中，总体上报告最多的胃肠道症状是吞咽困难、流涎、体重变化、食管炎、胃轻瘫、便秘、腹泻和吸收不良。我们详细报告了特发性震颤、不宁腿综合征、舞蹈病和脊髓小脑共济失调中胃肠道症状的频率、特征、病理生理学和治疗。还总结了在肌张力障碍、发作性运动障碍、迟发性运动障碍、肌阵挛和非 SCA 共济失调中有限的 GI 疾病可用数据。
我们进行系统综述的目的是引起人们注意，尽管运动过多性运动障碍和共济失调主要是运动障碍，但也可能涉及胃肠道系统。提高对运动过多性运动障碍和共济失调中胃肠道症状负担的认识，可以促进该领域的新研究兴趣，并改善患者的护理。
