关于尿胃蛋白酶原A表型和血清胃蛋白酶原A水平的双生子研究。

Twin studies on urinary pepsinogen A phenotypes and serum pepsinogen A levels.

作者信息

Pronk J C, Boomsma D I, Pals G, Frants R R, Overbeke M, Meuwissen S G, Orlebeke J F, Eriksson A W

机构信息

Institute of Human Genetics, Free University, Amsterdam; The Netherlands.

出版信息

Acta Genet Med Gemellol (Roma). 1987;36(4):517-21. doi: 10.1017/s0001566000006899.

DOI:10.1017/s0001566000006899

PMID:3454514

Abstract

Urinary pepsinogen A (PGA or PG I) phenotypes and serum PGA levels were studied in MZ and DZ twins and their parents. In 45 out of 48 MZ twin pairs PGA patterns were completely identical, while 3 MZ twin pairs showed minor differences in the relative intensity of the Pg5 isozymogen. This suggests that the intensity of this isozymogen may be influenced by nongenetic factors. There was little difference in the interclass correlations of serum PGA levels between MZ and DZ twins, indicating a large contribution of common environmental factors to serum PGA levels. This is in contrast with previous studies.

摘要

对同卵双胞胎（MZ）和异卵双胞胎（DZ）及其父母的尿胃蛋白酶原A（PGA或PG I）表型和血清PGA水平进行了研究。在48对MZ双胞胎中，有45对的PGA模式完全相同，而3对MZ双胞胎在Pg5同工酶原的相对强度上存在微小差异。这表明该同工酶原的强度可能受非遗传因素影响。MZ和DZ双胞胎血清PGA水平的组内相关性差异不大，表明共同环境因素对血清PGA水平有很大影响。这与先前的研究结果相反。