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在一项为期九个月的对照研究中,一种新的治疗性饮食可显著降低特应性皮炎犬的药物评分和瘙痒。

A novel therapeutic diet can significantly reduce the medication score and pruritus of dogs with atopic dermatitis during a nine-month controlled study.

机构信息

Royal Canin SAS, Aimargues, France.

Clinic for Small Animal Internal Medicine, Vetsuisse Faculty University of Zurich, Winterthurerstrasse 260, Zurich, 8057, Switzerland.

出版信息

Vet Dermatol. 2022 Feb;33(1):55-e18. doi: 10.1111/vde.13020. Epub 2021 Sep 20.

Abstract

BACKGROUND

Canine atopic dermatitis (cAD) is a common chronic relapsing pruritic skin disease for which management commonly relies on life-long use of immunomodulatory drugs. A number of the medications used are associated with adverse effects and the potential for complications during long-term use.

HYPOTHESIS

The goal of the study was to determine if a complete and balanced diet formulated for therapeutic benefit could contribute towards management of cAD. We hypothesised that the diet would reduce pruritus while also reducing the requirement for medication during the study period.

ANIMALS, MATERIALS AND METHODS: Forty privately owned dogs, having undergone a comprehensive diagnosis for cAD, were randomly allocated to two groups, each group being fed one of two diets (test or control) for up to nine months. We assessed pruritus, Canine Atopic Dermatitis Extent and Severity Index-(4th iteration) and medication score, the latter reflecting the medication required to maintain a satisfactory quality of life for the animal.

RESULTS

Both diets were well-accepted and -tolerated. There was a significant improvement in the pruritus score after three months of feeding the therapeutic diet (P = 0.0001). No such improvement was observed at any time point in the group of dogs given the control diet. There was a reduced drug requirement for dogs receiving the therapeutic diet after three months (P = 0.058), and that decrease was significant at six months (P = 0.021) and nine months (P = 0.018). No improvement was seen at any time point in the control group.

CONCLUSION

The results suggest that a novel therapeutic diet can assist in the management of cAD by helping to control pruritus and reducing reliance on medication.

摘要

背景

犬特应性皮炎(cAD)是一种常见的慢性复发性瘙痒性皮肤病,其管理通常依赖于免疫调节药物的终身使用。许多使用的药物与不良反应有关,并且在长期使用过程中存在潜在并发症的风险。

假设

该研究的目的是确定一种针对治疗益处而配制的完整均衡饮食是否有助于犬特应性皮炎的管理。我们假设该饮食将减轻瘙痒,同时减少研究期间对药物的需求。

动物、材料和方法:40 只私人拥有的狗经过全面诊断为 cAD,随机分为两组,每组喂食两种饮食(试验或对照)之一,最长可达九个月。我们评估了瘙痒、犬特应性皮炎严重程度指数(第 4 次迭代)和药物评分,后者反映了维持动物生活质量所需的药物。

结果

两种饮食均被良好接受和耐受。在喂食治疗饮食三个月后,瘙痒评分显著改善(P = 0.0001)。在给予对照饮食的狗中,任何时间点均未观察到这种改善。在接受治疗饮食的狗中,三个月后药物需求减少(P = 0.058),六个月时(P = 0.021)和九个月时(P = 0.018)显著减少。在对照组中,任何时间点均未观察到改善。

结论

结果表明,一种新型治疗饮食可以通过帮助控制瘙痒和减少对药物的依赖来辅助犬特应性皮炎的管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/696a/9292154/46be7e3eeeb6/VDE-33-55-g001.jpg

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