Animal Dermatology and Allergy Specialists, Wayne, NJ, USA.
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA.
Vet Dermatol. 2022 Aug;33(4):329-e77. doi: 10.1111/vde.13077. Epub 2022 May 29.
Cannabidiol (CBD) and cannabidiolic acid (CBDA) are reported to have antinociceptive, immunomodulatory and anti-inflammatory actions.
To determine if CBD/CBDA is an effective therapy for canine atopic dermatitis (cAD).
Thirty-two privately owned dogs with cAD.
Prospective, randomised, double-blinded, placebo-controlled study. Concurrent therapies were allowed if remained unchanged. Dogs were randomly assigned to receive either 2 mg/kg of an equal mix of CBD/CBDA (n = 17) or placebo for 4 weeks. On Day (D)0, D14 and D28, Canine Atopic Dermatitis Extent and Severity Index, 4th iteration (CADESI-04) and pruritus Visual Analog Scale (pVAS) scores were determined by investigators and owners, respectively. Complete blood count, serum biochemistry profiles and cytokine bioassays were performed on serum collected on D0 and D28.
There was no significant difference in CADESI-04 from D0 to D14 (p = 0.42) or D28 (p = 0.51) in either group. pVAS scores were significantly lower for the treatment group at D14 (p = 0.04) and D28 (p = 0.01) and a significant change in pVAS from baseline was seen at D14 (p = 0.04) and not D28 (p = 0.054) between groups. There was no significant difference in serum levels of interleukin (IL)-6, IL-8, monocyte chemoattractant protein - 1, IL-31 or IL-34 between groups at D0 or D28. Elevated alkaline phosphatase was observed in four of 17 treatment group dogs.
CBD/CBDA as an adjunct therapy decreased pruritus, and not skin lesions associated with cAD in dogs.
大麻二酚 (CBD) 和大麻二酚酸 (CBDA) 具有镇痛、免疫调节和抗炎作用。
确定 CBD/CBDA 是否对犬特应性皮炎 (cAD) 有效。
32 只患有 cAD 的私人拥有的狗。
前瞻性、随机、双盲、安慰剂对照研究。如果保持不变，允许同时进行其他治疗。狗被随机分配接受 2mg/kg 的 CBD/CBDA 混合物 (n=17) 或安慰剂治疗 4 周。在第 0 天 (D)、第 14 天和第 28 天，研究者和主人分别确定犬特应性皮炎严重程度指数第四版 (CADESI-04) 和瘙痒视觉模拟量表 (pVAS) 评分。在 D0 和 D28 采集血清进行全血细胞计数、血清生化谱和细胞因子生物测定。
两组在 D0 至 D14 天 (p=0.42) 或 D28 天 (p=0.51) 时，CADESI-04 均无显著差异。治疗组在 D14 天 (p=0.04) 和 D28 天 (p=0.01) 的 pVAS 评分明显较低，并且在 D14 天 (p=0.04) 而不是 D28 天 (p=0.054) 之间组之间的 pVAS 从基线开始有显著变化。在 D0 或 D28 时，两组之间的白细胞介素 (IL)-6、IL-8、单核细胞趋化蛋白-1、IL-31 或 IL-34 的血清水平均无显著差异。在 17 只治疗组狗中，有 4 只狗的碱性磷酸酶升高。
CBD/CBDA 作为辅助治疗可减轻犬特应性皮炎相关的瘙痒，而不是皮肤病变。
