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Low seropositivity and suboptimal neutralisation rates in patients fully vaccinated against COVID-19 with B-cell malignancies.接受针对新冠病毒病全剂量疫苗接种的B细胞恶性肿瘤患者血清阳性率低且中和率未达最佳水平。
Br J Haematol. 2021 Dec;195(5):706-709. doi: 10.1111/bjh.17836. Epub 2021 Sep 21.
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Humoral and cellular responses to SARS-CoV-2 in patients with B-cell haematological malignancies improve with successive vaccination.B 细胞血液恶性肿瘤患者对 SARS-CoV-2 的体液和细胞反应随着连续接种疫苗而改善。
Br J Haematol. 2023 Sep;202(6):1091-1103. doi: 10.1111/bjh.18962. Epub 2023 Jul 4.
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Int Immunopharmacol. 2022 Sep;110:109046. doi: 10.1016/j.intimp.2022.109046. Epub 2022 Jul 12.

本文引用的文献

1
Bamlanivimab plus Etesevimab in Mild or Moderate Covid-19.巴尼韦单抗/依特司韦单抗在轻中度 COVID-19 中的应用。
N Engl J Med. 2021 Oct 7;385(15):1382-1392. doi: 10.1056/NEJMoa2102685. Epub 2021 Jul 14.
2
Antibody responses after SARS-CoV-2 vaccination in patients with lymphoma.淋巴瘤患者接种新型冠状病毒疫苗后的抗体反应。
Lancet Haematol. 2021 Aug;8(8):e542-e544. doi: 10.1016/S2352-3026(21)00199-X. Epub 2021 Jul 2.
3
BNT162b2 COVID-19 vaccine is significantly less effective in patients with hematologic malignancies.BNT162b2 COVID-19 疫苗在血液恶性肿瘤患者中的有效性显著降低。
Am J Hematol. 2021 Oct 1;96(10):1195-1203. doi: 10.1002/ajh.26284. Epub 2021 Jul 14.
4
Vaccine response following anti-CD20 therapy: a systematic review and meta-analysis of 905 patients.抗 CD20 治疗后的疫苗反应:905 例患者的系统评价和荟萃分析。
Blood Adv. 2021 Jun 21;5(12):2624-2643. doi: 10.1182/bloodadvances.2021004629.
5
Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection.中和抗体水平高度预测对有症状的 SARS-CoV-2 感染的免疫保护作用。
Nat Med. 2021 Jul;27(7):1205-1211. doi: 10.1038/s41591-021-01377-8. Epub 2021 May 17.
6
Efficacy of the BNT162b2 mRNA COVID-19 vaccine in patients with chronic lymphocytic leukemia.BNT162b2 mRNA新冠疫苗在慢性淋巴细胞白血病患者中的疗效
Blood. 2021 Jun 10;137(23):3165-3173. doi: 10.1182/blood.2021011568.
7
REGN-COV2, a Neutralizing Antibody Cocktail, in Outpatients with Covid-19.REGN-COV2,一种中和抗体鸡尾酒疗法,用于治疗门诊新冠患者。
N Engl J Med. 2021 Jan 21;384(3):238-251. doi: 10.1056/NEJMoa2035002. Epub 2020 Dec 17.
8
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK.ChAdOx1 nCoV-19 疫苗(阿斯利康)对 SARS-CoV-2 的安全性和有效性:巴西、南非和英国四项随机对照试验的中期分析。
Lancet. 2021 Jan 9;397(10269):99-111. doi: 10.1016/S0140-6736(20)32661-1. Epub 2020 Dec 8.
9
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine.BNT162b2 mRNA 新冠病毒疫苗的安全性和有效性。
N Engl J Med. 2020 Dec 31;383(27):2603-2615. doi: 10.1056/NEJMoa2034577. Epub 2020 Dec 10.
10
Outcomes of patients with hematologic malignancies and COVID-19: a systematic review and meta-analysis of 3377 patients.血液系统恶性肿瘤合并 COVID-19 患者的结局:对 3377 例患者的系统评价和荟萃分析。
Blood. 2020 Dec 17;136(25):2881-2892. doi: 10.1182/blood.2020008824.

Low seropositivity and suboptimal neutralisation rates in patients fully vaccinated against COVID-19 with B-cell malignancies.

作者信息

Fox Thomas A, Kirkwood Amy A, Enfield Louise, O'Reilly Maeve, Arulogun Suzanne, D'Sa Shirley, O'Nions Jenny, Kavi Janki, Vitsaras Evan, Townsend William, Burns Siobhan O, Gohil Satyen H, Cwynarski Kate, Thomson Kirsty J, Noursadeghi Mahdad, Heyderman Robert S, Rampling Tommy, Ardeshna Kirit M, McCoy Laura E, Morris Emma C

机构信息

UCL Institute of Immunity and Transplantation, University College London, London, UK.

Department of Clinical Haematology, University College London Hospitals NHS Foundation Trust, London, UK.

出版信息

Br J Haematol. 2021 Dec;195(5):706-709. doi: 10.1111/bjh.17836. Epub 2021 Sep 21.

DOI:10.1111/bjh.17836
PMID:34545952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8653163/
Abstract
摘要