Cultivation Base of Guangxi Key Laboratory for Agro-Environment and Agro-Products Safety, National Demonstration Center for Experimental Plant Science Education, College of Agriculture, Guangxi University, Nanning 530004, China.
Department of Agriculture, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj 8100, Bangladesh.
J Agric Food Chem. 2021 Oct 20;69(41):12295-12304. doi: 10.1021/acs.jafc.1c03284. Epub 2021 Sep 21.
The correlation of and assays for determining bioavailable Cd amounts in vegetables is limited. Herein, the correlations between Cd relative bioavailability (Cd-RBA) in rat models and Cd bioaccessibility in four assays were examined in vegetables. Results showed that the combined liver plus kidney data provided the appropriate endpoint and was used as a biomarker to estimate Cd-RBA. The Cd-RBA was negatively correlated with the mole ratio of Ca/Cd and Fe/Cd in vegetables. Strong correlations were found from physiologically based extraction test (PBET) and gastrointestinal (IVG) ( = 0.66-0.69). We concluded that PBET and IVG were optimal models for Cd-RBA determination in vegetables. The nutritional elements in the vegetables could affect Cd absorption. Furthermore, the Cd bioavailability in vegetables should be considered because risk estimates solely based on the total Cd concentration in vegetables would overestimate Cd intake.
测定蔬菜中生物可利用态镉含量的 和 分析之间的相关性有限。本研究旨在探讨蔬菜中大鼠模型相对生物有效性（Cd-RBA）与四种 分析方法中镉生物可给性之间的相关性。结果表明，联合肝加肾数据提供了适当的终点，并被用作估计 Cd-RBA 的生物标志物。Cd-RBA 与蔬菜中 Ca/Cd 和 Fe/Cd 的摩尔比呈负相关。从基于生理学的提取试验（PBET）和 胃肠道（IVG）中发现了很强的 相关性（ = 0.66-0.69）。我们得出结论，PBET 和 IVG 是测定蔬菜中 Cd-RBA 的最佳模型。蔬菜中的营养元素可能会影响镉的吸收。此外，应该考虑蔬菜中的镉生物利用度，因为仅基于蔬菜中总镉浓度的风险估计会高估镉的摄入量。
