Departments of Epidemiology and Medicine and Welch Center for Prevention, Epidemiology and Clinical Research, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD.
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Jongno-gu, Seoul, Korea.
Menopause. 2021 Sep 20;28(12):1330-1339. doi: 10.1097/GME.0000000000001863.
Muscle strength progressively decreases after menopause. Hand grip strength (HGS) reflects overall muscle strength and may be associated with health-related quality of life (HRQoL). We aimed to assess the association between HGS and HRQoL in postmenopausal women.
We used nationally representative data on 6,059 postmenopausal women from the Korea National Health and Nutrition Examination Survey (2014-2018). HGS was determined as the maximum value in kilograms (kg) achieved using either hand. HRQoL was estimated using the European Quality of Life Questionnaire-Five Dimensions (EQ-5D) questionnaire. The prevalence ratios of having moderate/severe problems on the EQ-5D were evaluated with adjustment for covariates using complex survey analysis.
The prevalence of having a problem in at least one of the HRQoL dimensions among postmenopausal women was 43.6%. Compared with participants with the lowest quintile of HGS, women in the highest quintile had a significantly lower prevalence of moderate/severe problems in most dimensions (fully adjusted prevalence ratios [95% confidence intervals]; 0.73 [0.60-0.89], 0.45 [0.28-0.72], 0.52 [0.38-0.71], 0.74 [0.63-0.87], and 0.91 [0.70-1.18] for mobility, self-care, usual activity, pain/discomfort, and anxiety/depression, respectively). The associations between HGS and EQ-5D index were stronger among the participants who were older (65-79 y), had a higher body mass index (≥ 25.0 kg/m2), had low physical activity, had a longer duration since menopause (≥ 10 y), and had a chronic disease.
Higher HGS was associated with a lower prevalence of moderate/severe problems in each dimension of the EQ-5D in postmenopausal women. These associations were more apparent in individuals who were older, had higher body mass index, or had a chronic disease.
绝经后肌肉力量逐渐下降。手握力（HGS）反映整体肌肉力量，可能与健康相关的生活质量（HRQoL）有关。我们旨在评估绝经后妇女的 HGS 与 HRQoL 之间的关系。
我们使用了韩国国家健康和营养检查调查（2014-2018 年）中 6059 名绝经后妇女的全国代表性数据。HGS 是通过使用单手达到的最大公斤数（kg）确定的。使用欧洲生活质量问卷-五个维度（EQ-5D）问卷估计 HRQoL。使用复杂调查分析调整协变量后，评估了 EQ-5D 至少一个维度存在中度/重度问题的患病率比。
绝经后妇女中至少有一个 HRQoL 维度存在问题的比例为 43.6%。与 HGS 最低五分位数的参与者相比，HGS 最高五分位数的女性在大多数维度上中度/重度问题的患病率显著较低（完全调整后的患病率比[95%置信区间]；0.73[0.60-0.89]，0.45[0.28-0.72]，0.52[0.38-0.71]，0.74[0.63-0.87]和 0.91[0.70-1.18]，分别为移动性、自我护理、日常活动、疼痛/不适和焦虑/抑郁）。在年龄较大（65-79 岁）、身体质量指数较高（≥25.0kg/m2）、体力活动较少、绝经后时间较长（≥10 年）和患有慢性病的参与者中，HGS 与 EQ-5D 指数之间的关联更强。
较高的 HGS 与绝经后妇女 EQ-5D 每个维度中度/重度问题的患病率较低相关。这些关联在年龄较大、身体质量指数较高或患有慢性病的个体中更为明显。
