雌二醇和孕酮在子宫平滑肌瘤及妊娠子宫肌层中的结合

Estradiol and progesterone binding in uterine leiomyomata and pregnant myometrium.

作者信息

Nardelli G B, Mega M, Bertasi M, Siliotti F

机构信息

Institute of Obstetrics and Gynaecology, University of Padua, Italy.

出版信息

Clin Exp Obstet Gynecol. 1987;14(3-4):155-60.

PMID:3454723

Abstract

In order to verify the endogenous steroid influences on the myometrium, we compared the receptor status in 18 specimens of uterine leiomyomata and 31 specimens of pregnant myometrium. 17-beta-Estradiol and Progesterone receptors were assayed in the cytosol and nuclear extracts. In the uterine leiomyomata we observed the following mean values: PgR/c 279 fmol/mg, PgR/n 89 fmol/mg, ER/c 52.5 fmol/mg, ER/n 12.3 fmol/mg. In the pregnant myometrium we observed the following mean values: PgR/c 5.86 fmol/mg, PgR/n 166 fmol/mg, ER/c 0.76 fmol/mg, ER/n 1.65. It was concluded that direct correlation between estrogen power and progesterone receptor replenishment in the nucleus exists.

摘要

为了验证内源性类固醇对子宫肌层的影响，我们比较了18例子宫平滑肌瘤标本和31例妊娠子宫肌层标本中的受体状态。对胞浆和核提取物中的17-β-雌二醇和孕酮受体进行了检测。在子宫平滑肌瘤中，我们观察到以下平均值：胞浆孕酮受体（PgR/c）279 fmol/mg，核孕酮受体（PgR/n）89 fmol/mg，胞浆雌激素受体（ER/c）52.5 fmol/mg，核雌激素受体（ER/n）12.3 fmol/mg。在妊娠子宫肌层中，我们观察到以下平均值：PgR/c 5.86 fmol/mg，PgR/n 166 fmol/mg，ER/c 0.76 fmol/mg，ER/n 1.65。得出的结论是，雌激素水平与细胞核中孕酮受体补充之间存在直接相关性。