Nardelli G B, Mega M, Bertasi M, Siliotti F
Institute of Obstetrics and Gynaecology, University of Padua, Italy.
Clin Exp Obstet Gynecol. 1987;14(3-4):155-60.
In order to verify the endogenous steroid influences on the myometrium, we compared the receptor status in 18 specimens of uterine leiomyomata and 31 specimens of pregnant myometrium. 17-beta-Estradiol and Progesterone receptors were assayed in the cytosol and nuclear extracts. In the uterine leiomyomata we observed the following mean values: PgR/c 279 fmol/mg, PgR/n 89 fmol/mg, ER/c 52.5 fmol/mg, ER/n 12.3 fmol/mg. In the pregnant myometrium we observed the following mean values: PgR/c 5.86 fmol/mg, PgR/n 166 fmol/mg, ER/c 0.76 fmol/mg, ER/n 1.65. It was concluded that direct correlation between estrogen power and progesterone receptor replenishment in the nucleus exists.
为了验证内源性类固醇对子宫肌层的影响，我们比较了18例子宫平滑肌瘤标本和31例妊娠子宫肌层标本中的受体状态。对胞浆和核提取物中的17-β-雌二醇和孕酮受体进行了检测。在子宫平滑肌瘤中，我们观察到以下平均值：胞浆孕酮受体（PgR/c）279 fmol/mg，核孕酮受体（PgR/n）89 fmol/mg，胞浆雌激素受体（ER/c）52.5 fmol/mg，核雌激素受体（ER/n）12.3 fmol/mg。在妊娠子宫肌层中，我们观察到以下平均值：PgR/c 5.86 fmol/mg，PgR/n 166 fmol/mg，ER/c 0.76 fmol/mg，ER/n 1.65。得出的结论是，雌激素水平与细胞核中孕酮受体补充之间存在直接相关性。
