Wilson E A, Yang F, Rees E D
Obstet Gynecol. 1980 Jan;55(1):20-4.
To explain the sensitivity of uterine leiomyomata to endogenous and exogenous estrogens, specific cytosol receptor proteins for estradiol-17 beta and progesterone were found in tissue from uterine leiomyomata and compared with the concentrations of receptors in normal myometrium and endometrium from the same patient. The concentration of cytoplasmic estrogen receptors in leiomyomata (40.5 +/- 7.6 cytoplasmic estrogen receptors in leiomyomata (40.5 +/- 7.6 fmole/mg cytosol proteins, mean +/- SEM) was significantly greater than that found in myometrium (16.5 +/- 1.5) and significantly less than that found in endometrium (131 +/- 15.1). The concentration in leiomyomata of cytoplasmic progesterone receptors (104.4 +/- 41.2 fmole/mg cytosol protein, mean +/- SEM) was also greater than that found in myometrium (80.8 +/- 29.9) and less than that of endometrium (194.7 +/- 5.5); however, individual variation precluded statistical significance. The presence of cytoplasmic receptor proteins in myomatous tissues explains the sensitivity of the leiomyoma to endogenous or exogenous steroids and may provide information useful in the clinical management of this neoplastic disorder.
为了解释子宫平滑肌瘤对内源性和外源性雌激素的敏感性，研究人员在子宫平滑肌瘤组织中发现了特异性的雌二醇 - 17β和孕酮胞浆受体蛋白，并将其与同一患者正常子宫肌层和子宫内膜中的受体浓度进行了比较。子宫平滑肌瘤中细胞质雌激素受体的浓度（40.5±7.6飞摩尔/毫克胞浆蛋白，均值±标准误）显著高于子宫肌层中的浓度（16.5±1.5），且显著低于子宫内膜中的浓度（131±15.1）。子宫平滑肌瘤中细胞质孕酮受体的浓度（104.4±41.2飞摩尔/毫克胞浆蛋白，均值±标准误）也高于子宫肌层中的浓度（80.8±29.9），低于子宫内膜中的浓度（194.7±5.5）；然而，个体差异使得差异无统计学意义。肌瘤组织中细胞质受体蛋白的存在解释了平滑肌瘤对内源性或外源性类固醇的敏感性，并可能为这种肿瘤性疾病的临床管理提供有用信息。
