Phillips A M, Browne B H, Allan D, Szczesny P J, Lee W R, Foulds W S
Tennent Institute of Ophthalmology, University of Glasgow.
Eye (Lond). 1987;1 ( Pt 6):680-5. doi: 10.1038/eye.1987.111.
Greene amelanotic melanoma transplanted to pigmented rabbit choroid provided the experimental model for studying photosensitisation treatment of choroidal melanoma. Administration of haematoporphyrin derivative (HPD) and subsequent photoradiation with green laser light destroyed much of the melanoma with minimal side effects to normal uvea. The results of treatment were documented by fundus photography and fluorescein angiography. By 24 hours, the irradiated melanoma and surrounding retina appeared whitened and necrotic, with complete non-perfusion of the area. Over the course of one week, the clinical appearance did not alter. Histopathology at 24 hours and 8 days confirmed massive central tumour necrosis, but in all cases this was subtotal. Viable cells were evident at the periphery and also along the base of the tumour. Experimental evaluation of treatment parameters is required before this technique can be recommended for human choroidal melanoma.
将格林无色素性黑色素瘤移植到有色素的兔脉络膜上，为研究脉络膜黑色素瘤的光致敏治疗提供了实验模型。给予血卟啉衍生物（HPD），随后用绿色激光进行光辐射，可破坏大部分黑色素瘤，对正常葡萄膜的副作用最小。通过眼底照相和荧光素血管造影记录治疗结果。到24小时时，照射的黑色素瘤和周围视网膜变白并坏死，该区域完全无灌注。在一周的时间里，临床表现没有改变。24小时和8天时的组织病理学证实有大量中央肿瘤坏死，但在所有病例中均为部分坏死。肿瘤周边以及肿瘤基底部可见存活细胞。在将该技术推荐用于人类脉络膜黑色素瘤之前，需要对治疗参数进行实验评估。
