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[光动力疗法在黑色素瘤诊断与治疗中的应用实验研究]

[Experimental studies on the usefulness of photodynamic method in diagnosis and treatment of melanoma].

作者信息

Kecik T, Switka-Wiecławska I, Kasprzak J, Graczyk A, Pratnicki A

机构信息

Kliniki Chorób Oczu AM, Warszawie.

出版信息

Klin Oczna. 1993 Aug;95(8):293-5.

PMID:8189688
Abstract

The authors present results of experimental studies on the usefulness of hematoporphyrin and laser in diagnosis and treatment of intraocular tumors. An amelanotic Greene melanoma was implanted into anterior chamber of 10 rabbits. After administration of HpD the tumor was irradiated with laser light of wavelengths 406 nm for diagnosis and 630 nm for selective destruction of neoplastic cells. During follow-up the tumor was growing pale and its gradual shrinkage was observed. In histopathological examination multiple area of necrosis with total destruction of blood vessels were found.

摘要

作者展示了关于血卟啉和激光在眼内肿瘤诊断与治疗中的效用的实验研究结果。将无黑色素的格林氏黑色素瘤植入10只兔子的前房。给予血卟啉衍生物(HpD)后,用波长406nm的激光照射肿瘤用于诊断,用630nm的激光照射以选择性破坏肿瘤细胞。在随访期间,肿瘤逐渐变淡,并观察到其逐渐缩小。在组织病理学检查中,发现多处坏死区域,血管完全被破坏。

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