Atherothrombosis Research Centre/Laboratory of Biochemistry, Department of Chemistry, University of Ioannina, 45110, Ioannina, Greece.
Curr Med Chem. 2022;29(34):5496-5509. doi: 10.2174/0929867328666210921161711.
Vascular aging is a crucial risk factor for atherosclerotic ischemic stroke. Vascular aging is characterized by oxidative stress, endothelial dysfunction, inflammation, intimal and media thickening, as well as the gradual development of arterial stiffness, among other pathophysiological features. Regarding oxidative stress, increased concentration of reactive oxygen and nitrogen species is linked to atherosclerotic ischemic stroke in vascular aging. Additionally, oxidative stress is associated with an inflammatory response. Inflammation is related to aging through the "inflammaging" theory, which is characterized by decreased ability to cope with a variety of stressors, in combination with an increased pro-inflammatory state. Vascular aging is correlated with changes in cerebral arteries that are considered predictors of the risk for atherosclerotic ischemic stroke. The aim of the present review is to present the role of oxidative stress and inflammation in vascular aging, as well as their involvement in atherosclerotic ischemic stroke.
血管老化是动脉粥样硬化性缺血性卒中的一个关键危险因素。血管老化的特征是氧化应激、内皮功能障碍、炎症、内膜和中膜增厚以及动脉僵硬度的逐渐发展等病理生理特征。关于氧化应激，活性氧和氮物种浓度的增加与血管老化中的动脉粥样硬化性缺血性卒中有关。此外，氧化应激与炎症反应有关。炎症与衰老有关，这一理论被称为“炎老化”，其特征是应对各种应激源的能力下降，同时促炎状态增加。血管老化与被认为是动脉粥样硬化性缺血性卒中风险预测因子的脑动脉变化有关。本综述的目的是阐述氧化应激和炎症在血管老化中的作用及其在动脉粥样硬化性缺血性卒中中的作用。
