Sowmiya S, Begum Rukaiah Fatma, Dhivya L S, Rajendran Praveen, Harikrishnan N, Singh S Ankul
Department of Pharmacology, Dr M.G.R. Educational and Research Institute, Chennai, Tamil Nadu, India.
Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh, India.
Front Pharmacol. 2025 May 30;16:1561688. doi: 10.3389/fphar.2025.1561688. eCollection 2025.
Ischemic stroke remains a leading cause of mortality and long-term disability worldwide, despite advancements in acute intervention and rehabilitation strategies. Traditional, Complementary, and Integrative Medicine (TCIM) systems; including herbal medicine, acupuncture, and mind-body interventions are increasingly being explored as adjunct therapies in stroke management. This narrative review evaluates the current evidence supporting TCIM approaches for ischemic stroke, highlighting their potential neuroprotective, anti-inflammatory, antioxidant, and cerebrovascular effects. Particular emphasis is placed on well-studied botanical interventions such as Bunge [Lamiaceae; Salviae miltiorrhizae radix et rhizoma], L. [Ginkgoaceae; Ginkgo folium], and C.A. Mey. [Araliaceae; Ginseng radix]. The review discusses the mechanisms of action, clinical trial outcomes, and integration challenges, while underscoring the need for standardization, quality control, and rigorous scientific validation. This work aims to support informed decisions regarding the integration of evidence-based TCIM practices into conventional stroke care protocols.
尽管急性干预和康复策略取得了进展,但缺血性中风仍然是全球死亡和长期残疾的主要原因。传统医学、补充医学和整合医学(TCIM)系统,包括草药、针灸和身心干预,越来越多地被探索作为中风管理的辅助疗法。这篇叙述性综述评估了支持TCIM治疗缺血性中风方法的现有证据,强调了它们潜在的神经保护、抗炎、抗氧化和脑血管作用。特别强调了经过充分研究的植物性干预措施,如丹参[唇形科;丹参根及根茎]、银杏叶[银杏科;银杏叶]和人参[五加科;人参根]。该综述讨论了作用机制、临床试验结果和整合挑战,同时强调了标准化、质量控制和严格科学验证的必要性。这项工作旨在支持有关将基于证据的TCIM实践纳入传统中风护理方案的明智决策。
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