Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, 1873 Rama 4 road, Pathumwan, Bangkok, 10330, Thailand.
J Med Case Rep. 2021 Sep 22;15(1):467. doi: 10.1186/s13256-021-03063-2.
Fixed dilated pupil after ophthalmic surgery or Urrets-Zavalia syndrome occurs after anterior segment surgery and usually relates to postoperative elevation of intraocular pressure. Urrets-Zavalia syndrome results in complaints of glare, halo, and photophobia. Retention of the viscoelastic agent during Implantable Collamer Lens implantation can result in postoperative elevation of intraocular pressure and Urrets-Zavalia syndrome. However, reversibility of pupillary dilatation is possible in some cases.
A 20-year-old Thai man with myopic astigmatism in both eyes underwent Implantable Collamer Lens implantation in the right eye. The preoperative slit-lamp examination of both eyes was normal, and no ectatic changes were detected from corneal tomography. One hour after the uncomplicated surgery of the right eye, intraocular pressure increased to 48 mmHg and was immediately controlled with antiglaucoma medications. Postoperative pupillary dilatation was detected, presumably due to effect of preoperative application of mydriatic drops. At postoperative day 1, the right pupil remained dilated but still reactive to light and pilocarpine 2% eye drops. Two weeks later, the left eye underwent the Implantable Collamer Lens implantation and showed neither postoperative increase in intraocular pressure nor postoperative pupillary dilatation. Two months after surgery, the dilatation of the right pupil partially reversed.
The findings of the right eye suggested diagnosis of Urrets-Zavalia syndrome. Compared with former reports, we noted an association between immediate control of elevation of postoperative intraocular pressure, light reactivity of the dilated pupil, and reactivity to pilocarpine 2% eye drops as potential predictors for reversibility of Urrets-Zavalia syndrome.
眼部手术后固定性瞳孔散大或 Urrets-Zavalia 综合征发生在前节手术后,通常与术后眼内压升高有关。Urrets-Zavalia 综合征导致畏光、眩光和光敏感的主诉。在可植入式 Collamer 透镜植入术中粘性剂的保留可能导致术后眼内压升高和 Urrets-Zavalia 综合征。然而,在某些情况下,瞳孔散大的可逆性是可能的。
一名 20 岁的泰国男性,双眼均有近视散光,右眼接受了可植入式 Collamer 透镜植入术。双眼术前裂隙灯检查正常,角膜断层摄影术未发现扩张性改变。右眼手术顺利完成 1 小时后,眼内压升高至 48mmHg,立即用抗青光眼药物控制。术后发现瞳孔散大,推测是由于术前应用散瞳剂的影响。术后第 1 天,右眼瞳孔仍扩大,但对光仍有反应,并用 2%毛果芸香碱滴眼。两周后,左眼接受了可植入式 Collamer 透镜植入术,术后既没有眼压升高,也没有瞳孔散大。术后 2 个月,右眼瞳孔散大部分恢复。
右眼的发现提示诊断为 Urrets-Zavalia 综合征。与以往的报告相比,我们注意到术后眼压升高的即刻控制、扩张瞳孔的光反应性以及对 2%毛果芸香碱滴眼剂的反应性与 Urrets-Zavalia 综合征的可逆性之间存在关联。