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Tumours block protective muscle and nerve signals to cause cachexia.

作者信息

Zimmers Teresa A

出版信息

Nature. 2021 Oct;598(7879):37-38. doi: 10.1038/d41586-021-02492-9.

DOI:10.1038/d41586-021-02492-9
PMID:34548663
Abstract
摘要

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Neural Mechanisms of Cancer Cachexia.癌症恶病质的神经机制
Cancers (Basel). 2021 Aug 7;13(16):3990. doi: 10.3390/cancers13163990.
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Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia.BMP 信号通路紊乱和去神经支配促进癌症恶病质中的肌肉消耗。
Sci Transl Med. 2021 Aug 4;13(605). doi: 10.1126/scitranslmed.aay9592.
3
Muscle weakness caused by cancer and chemotherapy is associated with loss of motor unit connectivity.癌症和化疗引起的肌肉无力与运动单位连接性丧失有关。
Am J Cancer Res. 2021 Jun 15;11(6):2990-3001. eCollection 2021.
4
Phenotypic features of cancer cachexia-related loss of skeletal muscle mass and function: lessons from human and animal studies.癌症恶病质相关骨骼肌减少和功能丧失的表型特征：来自人体和动物研究的教训。
J Cachexia Sarcopenia Muscle. 2021 Apr;12(2):252-273. doi: 10.1002/jcsm.12678. Epub 2021 Mar 30.
5
Targeting the Activin Receptor Signaling to Counteract the Multi-Systemic Complications of Cancer and Its Treatments.靶向激活素受体信号通路以对抗癌症及其治疗的多系统并发症。
Cells. 2021 Feb 28;10(3):516. doi: 10.3390/cells10030516.
6
The Antiviral Drug Tilorone Is a Potent and Selective Inhibitor of Acetylcholinesterase.抗病毒药物噻洛酮是一种强效且选择性的乙酰胆碱酯酶抑制剂。
Chem Res Toxicol. 2021 May 17;34(5):1296-1307. doi: 10.1021/acs.chemrestox.0c00466. Epub 2021 Jan 5.
7
Advances in cancer cachexia: Intersection between affected organs, mediators, and pharmacological interventions.癌症恶病质的研究进展：受影响器官、介质和药物干预的交叉点。
Biochim Biophys Acta Rev Cancer. 2020 Apr;1873(2):188359. doi: 10.1016/j.bbcan.2020.188359. Epub 2020 Mar 25.
8
Neuromuscular junctions are stable in patients with cancer cachexia.神经肌肉接头在癌性恶病质患者中是稳定的。
J Clin Invest. 2020 Mar 2;130(3):1461-1465. doi: 10.1172/JCI128411.
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Effects of weight loss and sarcopenia on response to chemotherapy, quality of life, and survival.减肥和肌肉减少症对化疗反应、生活质量和生存的影响。
Nutrition. 2019 Nov-Dec;67-68:110539. doi: 10.1016/j.nut.2019.06.020. Epub 2019 Jun 28.
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Bone Morphogenetic Proteins: Promising Molecules for Bone Healing, Bioengineering, and Regenerative Medicine.骨形态发生蛋白：骨愈合、生物工程和再生医学中充满前景的分子
Vitam Horm. 2015;99:293-322. doi: 10.1016/bs.vh.2015.06.002. Epub 2015 Jul 15.