东南欧战争相关创伤后应激障碍中MAOA和SLC6A4基因变异的关联分析

Association Analysis of Maoa and Slc6a4 Gene Variation in South East European War Related Posttraumatic Stress Disorder.

作者信息

Kravić Nermina, Šabić Džananović Emina, Muminović Umihanić Mirnesa, Džubur Kulenović Alma, Sinanović Osman, Jakovljević Miro, Babić Dragan, Kučukalić Abdulah, Agani Ferid, Kučukalić Sabina, Bravo Mehmedbašić Alma, Goci Uka Aferdita, Haxhibeqiri Shpend, Haxhibeqiri Valdete, Hoxha Blerina, Aukst Margetić Branka, Jakšić Nenad, Cima Franc Ana, Rudan Duško, Pavlović Marko, Babić Romana, Ferić Bojić Elma, Marjanović Damir, Božina Nada, Ziegler Christiane, Wolf Christiane, Warrings Bodo, Domschke Katharina, Deckert Jürgen, Avdibegović Esmina

机构信息

Department of Psychiatry, University Clinical Centre Tuzla, Rate Dugonjića bb, 75000 Tuzla, Bosnia and Herzegovina,

出版信息

Psychiatr Danub. 2019 Jun;31(2):211-218. doi: 10.24869/psyd.2019.211.

DOI:10.24869/psyd.2019.211

PMID:31291228

Abstract

BACKGROUND

The aim of this study is to investigate the association of gene variations of the monoamine oxidase A (MAOA) and the serotonin transporter solute carrier family 6 member 4 (SLC6A4) gene with posttraumatic stress disorder (PTSD) severity and coping strategies in patients with war related PTSD.

SUBJECTS AND METHODS

The study included 747 individuals who had experienced war trauma in the South Eastern Europe conflicts between 1991 and 1999. Genotyping of the MAOA VNTR and SLC6A4 tandem repeat polymorphism in combination with rs25531 was done in 719 participants: 232 females and 487 males. Among them, 369 have had current or lifetime PTSD and 350 have had no PTSD symptoms. For psychometric approach we used the Clinician Administrated PTSD Scale (CAPS), the Brief Symptom Inventory (BSI), the adapted Hoffman-Lazarus Coping scale and a basic socio-demographic data questionnaire.

RESULTS

There were no significant intergroup (PTSD versus non PTSD) differences in the genotype distribution of MAOA and SLC6A4 gene polymorphisms. The primary finding of our study was that the MAOA short allele (MAOA-S) was nominally significantly associated with the severity of PTSD symptoms in the total subgroup of participants with lifetime PTSD; males for symptoms of hyperarrousal and females with symptoms of re-experience and hyperarousal. In our research the male subsample with current PTSD and MAOA-S genotype had nominally significantly higher scores for some positive coping strategies compared to those carrying the long allele genotype (MAOA-L). There was no significant association between the severity of PTSD symptoms, BSI phenotype, coping scores and the SLC6A4 genotype.

CONCLUSION

The present results support the notion that MAOA VNTR gene variation modulates development and recovery of posttraumatic stress disorder in a war traumatised population, but did not support a connection between SLC6A4 gene variations and war related PTSD.

摘要

背景

本研究旨在调查单胺氧化酶A（MAOA）基因变异和血清素转运体溶质载体家族6成员4（SLC6A4）基因与战争相关创伤后应激障碍（PTSD）患者的PTSD严重程度及应对策略之间的关联。

受试者与方法

本研究纳入了747名在1991年至1999年东南欧冲突中经历过战争创伤的个体。对719名参与者（232名女性和487名男性）进行了MAOA可变数目串联重复序列（VNTR）和SLC6A4串联重复多态性联合rs25531的基因分型。其中，369人有当前或终生PTSD，350人无PTSD症状。对于心理测量方法，我们使用了临床医生管理的PTSD量表（CAPS）、简明症状量表（BSI）、改编后的霍夫曼 - 拉扎勒斯应对量表和一份基本社会人口统计学数据问卷。

结果

MAOA和SLC6A4基因多态性的基因型分布在组间（PTSD组与非PTSD组）无显著差异。我们研究的主要发现是，MAOA短等位基因（MAOA - S）在终生患有PTSD的参与者总亚组中与PTSD症状严重程度名义上显著相关；在男性中与过度觉醒症状相关，在女性中与再体验和过度觉醒症状相关。在我们的研究中，当前患有PTSD且基因型为MAOA - S的男性亚组与携带长等位基因基因型（MAOA - L）的男性相比，在一些积极应对策略上的得分名义上显著更高。PTSD症状严重程度、BSI表型、应对得分与SLC6A4基因型之间无显著关联。