Centro Universitário São Camilo, Curso de Medicina, São Paulo, SP, Brasil.
Braz J Biol. 2021 Sep 20;83:e249209. doi: 10.1590/1519-6984.249209. eCollection 2021.
Alo vera is a centenary remedy use for minor wounds and burns, but its mechanism of wound healing has not been know since. This article will evaluate and gather evidence of the effectiveness and safety of the use of aloe vera in the treatment of burns. A systematic review was carried out on the databases: MEDLINE, LILACS, DECS, SCIELO, in the last 7 years, with the descriptors: "Aloe", "Burns" and "treatment". 16 articles were found. After using the exclusion criteria; research in non-humans and literature review; 5 articles were selected. The article Teplick et al. (2018) performed an in vitro clinical experiment in A. Vera solution, and demonstrated that there was proliferation and cell migration of human skin fibroblasts and keratinocytes, in addition to being protective in the death of keratonocytes. That is, it accelerates the healing of wounds. Muangman et al. (2016), evaluated 50 patients with 20% of the total body surface area burned with second-degree burns, between 18-60 years old, with half of the group receiving gauze dressings with soft paraffin containing 0.5% chlorhexidine acetate and the other half receiving polyester dressings containing extracts of medicinal plants mainly Aloe Vera. It had positive results, a higher healing speed and shorter hospital stay compared to the control group. Hwang et al. (2015) investigated the antioxidant effects of different extracts from 2,4,6,8,12 months of Aloe Vera. And the 6-month concentrated extract of 0.25 mg / mL had a higher content of flavonoids (9.750 mg catechin equivalent / g extract) and polyphenols (23.375 mg gallic acid equivalent / g extract) and the greater ferric reducing antioxidant power (0.047 mM equivalent ferrous sulfate / mg extract), that is, greater potential for free radical scavenging and also a protective effect against oxidative stress induced by tert-butyl hydroperoxide (t-BHP), suggesting evidence of a bioactive potential of A. vera . However, in the article Kolacz et al. (2014) suggested as an alternative treatment the use of Aloe Vera dressing in combination with honey, lanolin, olive oil, wheat germ oil, marshmallow root, wormwood, comfrey root, white oak bark, lobelia inflata, glycerin vegetable oil, beeswax and myrrh, without obtaining significant and conclusive results that would allow the conventional treatment of burns to be subsidized. Finally, in the article by Zurita and Gallegos (2017), it carried out a descriptive cross-sectional study with 321 people, both sexes between 17-76 years of age, of an inductive nature, exploring the experience of this population and their behavioral attitudes regarding the treatment of dermatoses. Aloe vera had 13.8% cited by individuals in the treatment of acne and 33.6% in the treatment of burns. Even with evidence that suggests the efficacy in the treatment of burns with the use of Aloe Vera extract, further clinical trials with larger sample space on the use of Aloe vera dressings in medium burns are suggested for further conclusions.
库拉索芦荟是一种用于治疗小伤口和烧伤的百年良药，但它的愈合机制至今仍不清楚。本文将评估和收集使用库拉索芦荟治疗烧伤的疗效和安全性的证据。在过去 7 年中，我们在 MEDLINE、LILACS、DECS、SCIELO 等数据库中使用“芦荟”、“烧伤”和“治疗”等词进行了系统评价。共发现 16 篇文章。使用排除标准后；非人类研究和文献综述；选择了 5 篇文章。Teplick 等人（2018 年）在芦荟溶液中进行了一项体外临床试验，证明了人类皮肤成纤维细胞和角质形成细胞的增殖和细胞迁移，此外对角质形成细胞的死亡有保护作用。也就是说，它可以加速伤口愈合。Muangman 等人（2016 年）评估了 50 名全身 20%面积烧伤的患者，年龄在 18-60 岁之间，其中一半的患者接受含有 0.5%醋酸洗必泰的软石蜡纱布敷料，另一半接受主要含有芦荟的药用植物提取物的聚酯敷料。结果表明，与对照组相比，它具有更高的愈合速度和更短的住院时间。Hwang 等人（2015 年）研究了不同月份（2、4、6、8、12 个月）库拉索芦荟提取物的抗氧化作用。浓度为 0.25mg/ml 的 6 个月浓缩提取物具有更高的类黄酮含量（9.750mg儿茶素当量/g提取物）和多酚含量（23.375mg没食子酸当量/g提取物）和更高的铁还原抗氧化能力（0.047mM 硫酸亚铁当量/mg 提取物），即具有更高的自由基清除能力，也对叔丁基过氧化物（t-BHP）诱导的氧化应激具有保护作用，表明芦荟具有生物活性潜力。然而，在 Kolacz 等人的文章中（2014 年）建议作为替代治疗，使用含有芦荟的敷料与蜂蜜、羊毛脂、橄榄油、小麦胚芽油、药蜀葵根、苦艾、毛地黄根、白橡木皮、半边莲、甘油植物油、蜂蜡和没药结合使用，没有取得显著和确凿的结果，无法支持常规烧伤治疗。最后，在 Zurita 和 Gallegos（2017 年）的文章中，对 321 名 17-76 岁的人群进行了描述性横断面研究，采用诱导性方法，探索了该人群的经验及其对治疗皮肤病的行为态度。13.8%的个体在治疗痤疮和 33.6%的个体在治疗烧伤时使用库拉索芦荟。即使有证据表明使用库拉索芦荟提取物治疗烧伤有效，但仍建议进一步进行更大样本空间的临床试验，以进一步研究使用库拉索芦荟敷料治疗中度烧伤的情况。
