库拉索芦荟中的生物活性化合物作为潜在的抗癌剂。

Lead bioactive compounds of Aloe vera as potential anticancer agent.

机构信息

School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India.

出版信息

Pharmacol Res. 2019 Oct;148:104416. doi: 10.1016/j.phrs.2019.104416. Epub 2019 Aug 27.

DOI:10.1016/j.phrs.2019.104416

Abstract

Aloe vera (Aloe barbadensis Miller) is a perennial succulent medicinal plant. It has been used as a traditional or folk medicine for thousands of years and claimed that it possesses wound and burn healing activities, and anti-inflammatory as well as immunomodulatory effects. In recent years, the use of Aloe vera has been growing as a dietary supplement. The pre-clinical studies over the last couple of decades uncover the potential therapeutic activities of Aloe vera and its bioactive compounds, especially against neoplastic disease. Such investigations indicate the possible preventive as well as therapeutic effects of Aloe vera against cancer. Here, we discuss the crucial bioactive compounds of Aloe vera that have been harnessed against cancer and also address several mechanisms of action of these lead bioactive compounds compared to other standard drugs involved in cancer prevention and treatment.

摘要

库拉索芦荟（Aloe barbadensis Miller）是一种多年生肉质药用植物。数千年来，它一直被用作传统或民间药物，据称具有伤口和烧伤愈合、抗炎和免疫调节作用。近年来，库拉索芦荟作为膳食补充剂的使用不断增加。过去几十年的临床前研究揭示了库拉索芦荟及其生物活性化合物的潜在治疗活性，特别是针对肿瘤疾病。这些研究表明库拉索芦荟对癌症具有可能的预防和治疗作用。在这里，我们讨论了库拉索芦荟中已被用于抗癌的关键生物活性化合物，并针对这些主要生物活性化合物与参与癌症预防和治疗的其他标准药物相比的几种作用机制进行了探讨。