Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Department of Pediatrics, University of Antioquia, Medellin, Colombia.
Methods Mol Biol. 2022;2345:1-15. doi: 10.1007/978-1-0716-1566-9_1.
In this chapter, we summarize the key principles involved in designing and conducting a rigorous systematic review focused on an intervention question. We provide key definitions on what systematic reviews and meta-analysis are and how they differ from other types of reviews. We cover the principles for designing a good systematic review question, research team, designing and conducting literature searches, screening and selecting studies, extracting data, assessing the risk of bias of the included studies, conducting qualitative and quantitative syntheses, and appraising the certainty of the body of evidence. Finally, we describe the best tools for reporting a systematic review and meta-analysis and for assessing its quality.
在本章中,我们总结了设计和进行严格的系统评价的关键原则,重点是干预问题。我们提供了系统评价和荟萃分析的关键定义,以及它们与其他类型的评价的区别。我们涵盖了设计一个好的系统评价问题、研究团队、设计和进行文献检索、筛选和选择研究、提取数据、评估纳入研究的偏倚风险、进行定性和定量综合以及评估证据体的确定性的原则。最后,我们描述了报告系统评价和荟萃分析以及评估其质量的最佳工具。