Department of Health Data Science, University of Liverpool, Liverpool, UK.
Methods Mol Biol. 2022;2345:263-278. doi: 10.1007/978-1-0716-1566-9_16.
This chapter provides a broad overview of the use of individual participant (sometimes referred to as patient) data (IPD ) within meta-analyses, the associated advantages of using IPD in meta-analysis compared to aggregate data, and when IPD should be used in meta-analysis.This chapter also outlines the steps of conducting an IPD meta-analysis, with practical guidance relating to requesting and obtaining IPD for meta-analysis. Challenges that can be associated with conducting an IPD meta-analysis are also discussed, including consideration of availability bias, when a subset of the relevant IPD is not available for meta-analysis.
本章提供了个体参与者（有时也称为患者）数据（IPD）在荟萃分析中的广泛概述，与使用汇总数据相比，使用 IPD 在荟萃分析中具有的相关优势，以及何时应在荟萃分析中使用 IPD。本章还概述了进行 IPD 荟萃分析的步骤，提供了与请求和获取 IPD 进行荟萃分析相关的实用指南。还讨论了进行 IPD 荟萃分析可能面临的挑战，包括考虑可用性偏差，即并非所有相关 IPD 都可用于荟萃分析的情况。
