Advanced Clinical Biosystems Institute and the Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.
Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, United States.
J Proteome Res. 2021 Oct 1;20(10):4627-4639. doi: 10.1021/acs.jproteome.1c00475. Epub 2021 Sep 22.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible coronavirus responsible for the pandemic coronavirus disease 2019 (COVID-19), which has had a devastating impact on society. Here, we summarize proteomic research that has helped elucidate hallmark proteins associated with the disease with respect to both short- and long-term diagnosis and prognosis. Additionally, we review the highly variable humoral response associated with COVID-19 and the increased risk of autoimmunity.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）是一种高传染性的冠状病毒，可引起大流行的 2019 年冠状病毒病（COVID-19），对社会造成了毁灭性影响。在这里，我们总结了有助于阐明与短期和长期诊断和预后相关的疾病特征蛋白的蛋白质组学研究。此外，我们还回顾了与 COVID-19 相关的高度可变的体液反应以及自身免疫风险增加的情况。
