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Urine proteome of COVID-19 patients.

作者信息

Li Yanchang, Wang Yihao, Liu Huiying, Sun Wei, Ding Baoqing, Zhao Yinghua, Chen Peiru, Zhu Li, Li Zhaodi, Li Naikang, Chang Lei, Wang Hengliang, Bai Changqing, Xu Ping

机构信息

State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics & Research and Development of New Drug of Chinese Academy of Medical Sciences, Beijing Institute of Lifeomics, Beijing, 102206, China.

Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, 100850, China.

出版信息

Urine (Amst). 2020;2:1-8. doi: 10.1016/j.urine.2021.02.001. Epub 2021 Mar 5.

DOI:10.1016/j.urine.2021.02.001
PMID:33688631
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7933783/
Abstract

The atypical pneumonia (COVID-19) caused by SARS-CoV-2 is a serious threat to global public health. However, early detection and effective prediction of patients with mild to severe symptoms remain challenging. The proteomic profiling of urine samples from healthy individuals, mild and severe COVID-19 positive patients with comorbidities can be clearly differentiated. Multiple pathways have been compromised after the COVID-19 infection, including the dysregulation of complement activation, platelet degranulation, lipoprotein metabolic process and response to hypoxia. This study demonstrates the COVID-19 pathophysiology related molecular alterations could be detected in the urine and the potential application in auxiliary diagnosis of COVID-19.

摘要

相似文献

[1]
Urine proteome of COVID-19 patients.

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[3]
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[4]
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[6]
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[7]
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引用本文的文献

[1]
Urinary Proteome and Exosome Analysis Protocol for the Discovery of Respiratory Diseases Biomarkers.

Biomolecules. 2025-1-3

[2]
Application of urinary peptide-biomarkers in trauma patients as a predictive tool for prognostic assessment, treatment and intervention timing.

Sci Rep. 2025-1-6

[3]
Diagnosis, Severity, and Prognosis from Potential Biomarkers of COVID-19 in Urine: A Review of Clinical and Omics Results.

Metabolites. 2024-12-22

[4]
Evaluation of serum and urine biomarkers for severe COVID-19.

Front Med (Lausanne). 2024-3-6

[5]
C1 esterase inhibitor-mediated immunosuppression in COVID-19: Friend or foe?

Clin Immunol Commun. 2022-12

[6]
Proteomic Profiling of Urine From Hospitalized Patients With Severe Pneumonia due to SARS-CoV-2 vs Other Causes: A Preliminary Report.

Open Forum Infect Dis. 2023-8-31

[7]
Urine Parameters in Patients with COVID-19 Infection.

Life (Basel). 2023-7-28

[8]
Urine-based multi-omic comparative analysis of COVID-19 and bacterial sepsis-induced ARDS.

Mol Med. 2023-1-26

[9]
Role of different types of RNA molecules in the severity prediction of SARS-CoV-2 patients.

Pathol Res Pract. 2023-2

[10]
The complement system in preeclampsia: a review of its activation and endothelial injury in the triad of COVID-19 infection and HIV-associated preeclampsia.

Obstet Gynecol Sci. 2023-7

本文引用的文献

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