Li Yanchang, Wang Yihao, Liu Huiying, Sun Wei, Ding Baoqing, Zhao Yinghua, Chen Peiru, Zhu Li, Li Zhaodi, Li Naikang, Chang Lei, Wang Hengliang, Bai Changqing, Xu Ping
State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Research Unit of Proteomics & Research and Development of New Drug of Chinese Academy of Medical Sciences, Beijing Institute of Lifeomics, Beijing, 102206, China.
Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, 100850, China.
Urine (Amst). 2020;2:1-8. doi: 10.1016/j.urine.2021.02.001. Epub 2021 Mar 5.
The atypical pneumonia (COVID-19) caused by SARS-CoV-2 is a serious threat to global public health. However, early detection and effective prediction of patients with mild to severe symptoms remain challenging. The proteomic profiling of urine samples from healthy individuals, mild and severe COVID-19 positive patients with comorbidities can be clearly differentiated. Multiple pathways have been compromised after the COVID-19 infection, including the dysregulation of complement activation, platelet degranulation, lipoprotein metabolic process and response to hypoxia. This study demonstrates the COVID-19 pathophysiology related molecular alterations could be detected in the urine and the potential application in auxiliary diagnosis of COVID-19.
由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的非典型肺炎（新冠肺炎）对全球公共卫生构成严重威胁。然而，对轻症至重症患者的早期检测和有效预测仍然具有挑战性。健康个体、患有合并症的轻症和重症新冠肺炎阳性患者尿液样本的蛋白质组学分析能够清晰区分。新冠肺炎感染后多个通路受到影响，包括补体激活失调、血小板脱颗粒、脂蛋白代谢过程以及对缺氧的反应。本研究表明，可在尿液中检测到与新冠肺炎病理生理学相关的分子改变及其在新冠肺炎辅助诊断中的潜在应用。
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