Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke/National Institutes of Health, Bethesda, MD, USA.
J Neuroendocrinol. 2021 Nov;33(11):e13039. doi: 10.1111/jne.13039. Epub 2021 Sep 22.
To this day, the identity of gonadotropin-releasing hormone (GnRH) progenitors remains unclear. However, the visualization of different developmental markers in subsets of GnRH neurons during early embryonic stages raised the possibility of at least two GnRH subpopulations. This observation led directly to a second question. Does visualization of different developmental markers in subsets of GnRH neurons reflect functional heterogeneity? This question remains unanswered, but as we learn more about the GnRH system, functional GnRH subpopulations become critically important to understanding GnRH function. This review addresses the development of the neuroendocrine GnRH system, specifically the heterogeneity of the GnRH neuroendocrine population.
时至今日，促性腺激素释放激素（GnRH）前体细胞的身份仍不清楚。然而，在早期胚胎阶段，GnRH 神经元的不同发育标记物在亚群中的可视化提出了至少存在两种 GnRH 亚群的可能性。这一观察结果直接引出了第二个问题。GnRH 神经元亚群中不同发育标记物的可视化是否反映了功能异质性？这个问题尚未得到解答，但随着我们对 GnRH 系统了解的增加，功能性 GnRH 亚群对于理解 GnRH 功能变得至关重要。本综述探讨了神经内分泌 GnRH 系统的发育，特别是 GnRH 神经内分泌群体的异质性。
