School of Petrochemical Engineering, Jiangsu Key Laboratory of Advanced Catalytic Materials & Technology, Changzhou University, Changzhou 213164, P. R. China.
School of Chemistry & Environmental Engineering, Jiangsu University of Technology, Changzhou 213001, P. R. China.
Org Biomol Chem. 2021 Oct 14;19(39):8442-8465. doi: 10.1039/d1ob01190a.
Arylation is a common behaviour in organic synthesis for the construction of complex structures, especially the biaryls. Among those reported arylation procedures, transition-metal-catalyzed direct C(sp)-H arylation has been rapidly developed in recent decades and has become a reliable alternative to traditional cross-coupling procedures using organometallic reagents. Great achievements in rhodium-catalyzed C(sp)-H arylation have been witnessed during the last decade. Aryl halides, simple arenes, aryl boronic acids, arylsilanes, aryl aldehyde, aryl carboxylic acid, diazides, . were successfully utilized as arylating reagents under rhodium-catalyzed conditions. In this review, recent achievements in rhodium-catalyzed arylations through C(sp)-H bond activation were summarized together with the mechanism discussions.
芳基化是有机合成中构建复杂结构的常见方法，特别是联芳烃。在已报道的芳基化方法中，过渡金属催化的直接 C(sp 2)-H 芳基化在最近几十年得到了迅速发展，并已成为使用有机金属试剂的传统交叉偶联方法的可靠替代方法。在过去十年中，铑催化的 C(sp 2)-H 芳基化已经取得了巨大的成就。芳基卤化物、简单芳烃、芳基硼酸、芳基硅烷、芳基醛、芳基羧酸、叠氮化物等在铑催化条件下都成功地被用作芳基化试剂。本文综述了近年来通过 C(sp 2)-H 键活化实现铑催化芳基化的最新进展，并对其反应机理进行了讨论。
