Relationship of nuclear magnetic resonance examinations to clinical data, cerebrospinal fluid findings and visual evoked potentials in multiple sclerosis.

We examined 150 patients with a 0.5 Tesla MR system. Fourteen patients were excluded from the study, because, in addition to the clinical signs of multiple sclerosis, they showed other abnormalities (spinal canal narrowing, embolic disease, Vitamin B12 deficiency, etc.). The results of the 136 examinations were related to the duration of disease, index of impairment on Kurtkze's disability scale, the clinical course, and the CSF and VEP results. The MR studies were evaluated in a semiquantitative manner. Patients with a long duration of disease demonstrated more changes than did cases with a short course. We found more periventricular confluences and more white matter plaques in the centrum semiovale. In addition, more lesions were seen in patients with a severe course of disease. All patients with negative CSF results (n = 13) showed positive MR examinations, and vice versa, patients with positive CSF findings showed negative MR results (n = 5). First results of a follow-up study demonstrate that most abnormalities in MR are not related to the clinical course or therapeutical procedure.