Fanani Maria Laura, Nocelli Natalia E, Zulueta Díaz Yenisleidy de Las Mercedes
Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina; Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), CONICET, Córdoba, Argentina.
Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina; Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), CONICET, Córdoba, Argentina.
Biochim Biophys Acta Biomembr. 2022 Feb 1;1864(1):183781. doi: 10.1016/j.bbamem.2021.183781. Epub 2021 Sep 21.
Surface-active amphiphiles find applications in a wide range of areas of industry such as agrochemicals, personal care, and pharmaceuticals. In many of these applications, interaction with cell membranes is a key factor for achieving their purpose. How do amphiphiles interact with lipid membranes? What are their bases for membrane specificity? Which biophysical properties of membranes are susceptible to modulation by amphiphilic membrane-effectors? What aspects of this interaction are important for performing their function? In our work on membrane biophysics over the years, questions like these have arisen and we now share some of our findings and discuss them in this review. This topic was approached focusing on the membrane properties and their alterations rather than on the amphiphile structure requirements for their interaction. Here, we do not aim to provide a comprehensive list of the modes of action of amphiphiles of biological interest but to help in understanding them.
表面活性两亲分子在广泛的工业领域有着应用，如农用化学品、个人护理产品和制药行业。在许多这类应用中，与细胞膜的相互作用是实现其目的的关键因素。两亲分子如何与脂质膜相互作用？它们膜特异性的基础是什么？膜的哪些生物物理特性易受两亲性膜效应剂的调节？这种相互作用的哪些方面对于其功能的发挥很重要？在我们多年来关于膜生物物理学的研究工作中，出现了诸如此类的问题，我们现将分享一些我们的发现并在本综述中进行讨论。探讨该主题时重点关注的是膜的特性及其变化，而非两亲分子相互作用的结构要求。在此，我们的目的不是提供一份具有生物学意义的两亲分子作用模式的全面清单，而是帮助理解它们。
