3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark - Zona Industrial da Gandra, Guimarães 4805-017, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães 4805-017, Portugal.
3B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark - Zona Industrial da Gandra, Guimarães 4805-017, Portugal; ICVS/3B's - PT Government Associate Laboratory, Braga, Guimarães 4805-017, Portugal.
Curr Opin Biotechnol. 2022 Feb;73:253-262. doi: 10.1016/j.copbio.2021.08.019. Epub 2021 Sep 21.
Cutaneous healing is a highly complex process that, if altered due to, for example, impaired vascularization, results in chronic wounds or repaired neotissue of poor quality. Significant progress has been achieved in promoting neotissue vascularization during tissue repair/regeneration. In this review, we discuss the strategies that have been explored and how each one of them contributes to regulate vascularization in the context of cutaneous wound healing from two different perspectives - biomaterial-based and a cell-based approaches. Finally, we discuss the implications of these findings on the development of the 'next generation' approaches to target vascularization in wound healing highlighting the importance of going beyond its contribution to regulate vascularization and take into consideration the temporal features of the healing process and of different types of wounds.
皮肤愈合是一个高度复杂的过程，如果由于血管化受损等原因而改变，会导致慢性伤口或修复的新生组织质量差。在促进组织修复/再生过程中的新生组织血管化方面已经取得了重大进展。在这篇综述中，我们讨论了已经探索的策略，以及它们中的每一个策略如何从生物材料和细胞两种不同的角度来调节皮肤伤口愈合中的血管化。最后，我们讨论了这些发现对开发“下一代”方法的影响，这些方法旨在针对伤口愈合中的血管化，强调不仅要考虑到血管化的调节作用，还要考虑到愈合过程和不同类型伤口的时间特征。
