Lange D J, Brin M F, Warner C L, Fahn S, Lovelace R E
Muscle Nerve. 1987 Jul-Aug;10(6):552-5. doi: 10.1002/mus.880100610.
We studied five patients who received local injections of botulinum toxin for dystonic disorders to determine if there had been any distant effects on neuromuscular transmission. No patient developed weakness or abnormalities on routine electrophysiologic testing. In all patients who received more than 245 U of toxin, SFEMG in the extensor digitorum communis muscle, a muscle distant to all those injected, was abnormal. Fiber density was increased in the two patients who received the largest cumulative dose. Jitter was maximally increased at slow firing rates, confirming its presynaptic basis. Our results reveal that there is an effect on neuromuscular transmission in muscles distant to those injected with botulinum toxin for dystonia.
我们研究了5例接受肉毒杆菌毒素局部注射治疗肌张力障碍性疾病的患者，以确定是否对神经肌肉传递产生了任何远隔效应。所有患者在常规电生理检查中均未出现肌无力或异常。在所有接受超过245单位毒素的患者中，指总伸肌（与所有注射部位距离较远的肌肉）的单纤维肌电图异常。接受最大累积剂量的2例患者的纤维密度增加。在慢放电频率时，颤抖最大程度增加，证实了其突触前基础。我们的结果显示，对于肌张力障碍患者，注射肉毒杆菌毒素部位以外的肌肉的神经肌肉传递受到了影响。
