Lange D J, Rubin M, Greene P E, Kang U J, Moskowitz C B, Brin M F, Lovelace R E, Fahn S
Department of Neurology, Neurological Institute, Columbia Presbyterian Medical Center, New York, NY 10032.
Muscle Nerve. 1991 Jul;14(7):672-5. doi: 10.1002/mus.880140711.
We used single fiber electromyography (SFEMG) to study 42 patients who had enrolled in a double-blind, placebo-controlled trial undertaken to assess the efficacy of botulinum toxin (BTX) injection of neck muscles to treat torticollis. SFEMG in a limb muscle was performed before treatment, 2, and 12 weeks after injection of placebo or BTX. Before treatment, the mean jitter was 26.8 microsec in patients who were to receive BTX, and 25.7 microsec in the placebo group. Two weeks after injection, mean jitter in the group receiving BTX was 43.6 microsec. In the placebo group, it was 26.5 microsec (P = less than .05). Twelve weeks after injection, mean jitter in the BTX group was 35.5; for the placebo group it was 24.5. Fiber density did not change in any patient during the study. There were no remote clinical effects of BTX. Injection of BTX into muscles affected with focal dystonia is a promising and safe treatment, but there are subclinical effects on uninjected muscles.
我们使用单纤维肌电图（SFEMG）对42例患者进行了研究，这些患者参加了一项双盲、安慰剂对照试验，该试验旨在评估肉毒杆菌毒素（BTX）注射颈部肌肉治疗斜颈的疗效。在注射安慰剂或BTX之前、注射后2周和12周，对肢体肌肉进行单纤维肌电图检查。治疗前，接受BTX治疗的患者平均颤抖为26.8微秒，安慰剂组为25.7微秒。注射后2周，接受BTX治疗的组平均颤抖为43.6微秒。在安慰剂组中，为26.5微秒（P<0.05）。注射后12周，BTX组平均颤抖为35.5；安慰剂组为24.5。在研究期间，没有患者的纤维密度发生变化。BTX没有远距离临床效应。将BTX注射到患有局灶性肌张力障碍的肌肉中是一种有前景且安全的治疗方法，但对未注射的肌肉有亚临床效应。
