链脲佐菌素诱导的糖尿病对易患菌斑大鼠牙龈炎的影响。

Effect of streptozotocin diabetes on gingivitis in plaque-susceptible rats.

作者信息

Takai N, Shinohara M, Yoshida Y, Ohura K, Mori M, Kakudo Y

出版信息

J Dent Res. 1986 Jan;65(1):49-52. doi: 10.1177/00220345860650010801.

DOI:10.1177/00220345860650010801

Abstract

The periodontal pocket probing depths of mandibular incisors of plaque-susceptible (Sus) rats, which spontaneously exhibit gingivitis with accumulation of plaque, were increased 20 days after injection of streptozotocin (70 mg/kg, i.v.). The accumulated plaque weights were also increased in Sus rats with streptozotocin diabetes, and a positive correlation was found between the plaque weights and the pocket depths. Histological findings showed that this inflammatory reaction in gingival tissue was higher and more extensive in diabetic Sus rats than in control Sus rats. These findings suggest that the accumulated plaque is the important factor for the severe breakdown of gingival tissue in this experimental model.

摘要

易患菌斑（Sus）大鼠的下颌切牙牙周袋探诊深度在注射链脲佐菌素（70mg/kg，静脉注射）20天后增加，这类大鼠会自发出现伴有菌斑积聚的牙龈炎。链脲佐菌素诱导的糖尿病Sus大鼠的菌斑积聚重量也增加，并且发现菌斑重量与牙周袋深度之间呈正相关。组织学结果显示，糖尿病Sus大鼠牙龈组织中的这种炎症反应比对照Sus大鼠更高且更广泛。这些发现表明，在该实验模型中，积聚的菌斑是牙龈组织严重破坏的重要因素。