Isogai E, Wakizaka H, Miura H, Isogai H, Hayashi M
Department of Preventive Dentistry, School of Dentistry, Higashi Nippon Gakuen University, Hokkaido, Japan.
Arch Oral Biol. 1993 Jan;38(1):75-8. doi: 10.1016/0003-9969(93)90158-i.
The functions of polymorphonuclear neutrophils (PMN) from SUS rats with naturally occurring gingivitis were examined by the luminol-dependent chemiluminescence (CL), adherence and bactericidal tests. SUS rats with pre-gingivitis showed lower CL responses of isolated PMNs and whole blood than control rats (RES rats). After plague formation and progression of gingivitis, the CL response gradually increased in SUS rats. RES rats had healthy gingiva and showed no increase in CL responses. Impaired PMN adherence was observed in SUS rats with pre-gingivitis but not in RES rats. PMNs from SUS rats with pre-gingivitis also showed lower bactericidal activity than those from RES rats. Dysfunction of PMNs might induce gingivitis as a result of decreased protection against periodontal pathogens and an elevated level of CL response can be recognized with progression of gingivitis.
通过鲁米诺依赖化学发光（CL）、黏附及杀菌试验，对患有自然发生性牙龈炎的SUS大鼠的多形核中性粒细胞（PMN）功能进行了检测。患有牙龈炎前期的SUS大鼠，其分离的PMN和全血的CL反应低于对照大鼠（RES大鼠）。在菌斑形成及牙龈炎进展后，SUS大鼠的CL反应逐渐增加。RES大鼠牙龈健康，CL反应未见增加。在患有牙龈炎前期的SUS大鼠中观察到PMN黏附受损，而RES大鼠未出现这种情况。患有牙龈炎前期的SUS大鼠的PMN杀菌活性也低于RES大鼠。PMN功能障碍可能由于对牙周病原体的保护作用降低而诱发牙龈炎，并且随着牙龈炎的进展，CL反应水平会升高。
