Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, United States.
The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Front Immunol. 2021 Sep 7;12:703326. doi: 10.3389/fimmu.2021.703326. eCollection 2021.
Nicotinic acid adenine dinucleotide 2'-phosphate (NAADP) is a naturally occurring nucleotide that has been shown to be involved in the release of Ca from intracellular stores in a wide variety of cell types, tissues and organisms. Current evidence suggests that NAADP may function as a trigger to initiate a Ca signal that is then amplified by other Ca release mechanisms. A fundamental question that remains unanswered is the identity of the NAADP receptor. Our recent studies have identified HN1L/JPT2 as a high affinity NAADP binding protein that is essential for the modulation of Ca channels.
烟酰胺腺嘌呤二核苷酸 2'-磷酸（NAADP）是一种天然存在的核苷酸，已被证明参与了各种细胞类型、组织和生物体中细胞内储存的 Ca 的释放。目前的证据表明，NAADP 可能作为触发剂发挥作用，启动 Ca 信号，然后被其他 Ca 释放机制放大。一个悬而未决的基本问题是 NAADP 受体的身份。我们最近的研究已经确定 HN1L/JPT2 是一种高亲和力的 NAADP 结合蛋白，对于 Ca 通道的调节是必不可少的。
