Meigs J W, Marrett L D, Ulrich F U, Flannery J T
J Natl Cancer Inst. 1986 Jan;76(1):1-8.
Linkage with records of the Connecticut Tumor Registry was used to determine cancer incidence in a cohort of workers (n = 984) at a benzidine manufacturing facility. Compared to the findings for the Connecticut population, there was a statistically significant excess of bladder tumor among male cohort members [standardized incidence ratio (SIR) = 343; 95% confidence limits (CL) = 148, 676; n = 830], which was confined to those with the highest estimated level of benzidine exposure (SIR = 1,303; CL = 479, 2,839; n = 105). No significantly elevated risks were found for cancers at other anatomic sites in men or at any anatomic sites in women; nor was there any pattern of increasing risk with increasing benzidine exposure for sites other than bladder. In addition, the elevated bladder cancer risk was greater for men first employed during the earliest years of the plant, namely, 1945-49 (SIR = 976; CL = 262, 2,498) as compared to those first employed in 1950-54 (SIR = 213; CL = 3, 1,184) after equalization of duration of follow-up. These results suggest that the major preventive measures instituted around 1950 may have reduced bladder cancer risk in this plant.
通过与康涅狄格肿瘤登记处的记录建立联系，来确定一家联苯胺制造工厂中一组工人（n = 984）的癌症发病率。与康涅狄格州人群的研究结果相比，男性队列成员中膀胱癌的发病率在统计学上显著高于预期[标准化发病比（SIR）= 343；95%置信区间（CL）= 148, 676；n = 830]，且这种情况仅限于估计联苯胺暴露水平最高的人群（SIR = 1,303；CL = 479, 2,839；n = 105）。在男性的其他解剖部位癌症或女性的任何解剖部位癌症中，均未发现显著升高的风险；除膀胱外，其他部位也没有随着联苯胺暴露增加而风险上升的模式。此外，在随访时间均等化后，与1950 - 1954年首次就业的男性相比，1945 - 1949年该厂最早几年首次就业的男性膀胱癌风险升高幅度更大（SIR = 976；CL = 262, 2,498）（SIR = 213；CL = 3, 1,184）。这些结果表明，1950年左右实施的主要预防措施可能降低了该厂的膀胱癌风险。
